News

ULS Distinguished Lecture - Pushing the envelope of super-resolution microscopy for sustained live imaging of rapid subcellular processes

The University Research Facility in Life Sciences (ULS) is organising a Distinguished Lecture on Super-resolution Fluorescence Microscopy by Prof. LI Dong, xinghua chair professor, new cornerstone investigator at school of life science, Tsinghua University. Prof. Li pioneered the development of advanced imaging systems, including high numerical aperture total internal reflection structured illumination microscopy (TIRF SIM, Science 2015 grazing incidence SIM (GI SIM, Cell 2018), 3D-SIM, nonlinear SIM, high speed lattice light sheet microscopy, and 3D high spatiotemporal resolution biomechanics microscopy. Complementing these hardware innovations, Prof. Li’s group also developed cutting edge algorithmic tools, such as the deep Fourier channel attention network (Nat Methods 2021, 2025) and the rationalized deep learning (rDL) architecture (Nat Biotech 2023, 2025). These advances enable the investigation of fragile and rapidly evolving subcellular bioprocesses with ultrahigh spatiotemporal resolution, facilitating unprecedented long term, multi colour imaging. In this lecture, Prof. Li will report their latest advances of how to synergize the developments in both optical front end and algorithmic back-end methodology to address these challenges and apply them to a wide variety of fragile and rapid evolving subcellular bioprocesses at ultra-high spatiotemporal resolution for unprecedented long time, multi-colour imaging. Details of the Distinguished Lecture are as follows: Date: 21 October, 2025 (Tuesday) Time: 3:00 pm to 4:15 pm Venue: Y716, Lee Shau Kee Building (Y Core), PolyU Lecture title: Pushing the envelope of super-resolution microscopy for sustained live imaging of rapid subcellular processes Online registration: https://forms.office.com/r/kqRDhLV3NJ   Should you have any enquiries, please contact Dr. Shuqi Zhang (Tel.: 3400 8923, shuqi.zhang@polyu.edu.hk) or Dr. Idy Ho (Tel.: 34008985, idyht.ho@polyu.edu.hk).

ULS Seminar - Abberior STED Super-resolution made simple and beautiful

The University Research Facility in Life Sciences (ULS) is co-organizing a seminar on stimulated emission depletion (STED) super-resolution microscope with Abberior and PTC. In this talk, the principle of STED and the advantages of STED over confocal imaging will be introduced. Unique technologies in Abberior STED and their superiorities in applications will be presented. You are cordially invited to attend a seminar on the STED super-resolution microscope. The details of the upcoming seminar are as follow:   Title: Abberior STED Super-resolution made simple and beautiful Date: 9 Oct 2025 (Thursday) Time: 10:30 am – 11:30 am Speaker:  Dr. Chi Leung SO (Business Development Manager, PTC) Venue: Y411, Block Y, PolyU   Should you have any enquiries, please contact Dr. Shuqi Zhang (shuqi.zhang@polyu.edu.hk) or Dr. Idy Ho (idyht.ho@polyu.edu.hk).   All are welcome!   Thank you for your attention.   University Research Facility in Life Sciences The Hong Kong Polytechnic University

(Change of schedule) ULS Seminar - Introducing the CytoFLEX mosaic Detection Module

The seminar "Introducing the CytoFLEX mosaic Detection Module"on 24 September (Wednesday) 10:30 a.m. has been rescheduled to 8 Oct (Wednesday) 10:30 a.m. due to the approach of Typhoon Ragasa.   Message from the University Research Facility in Life Sciences   CytoFLEX S Flow Cytometer with the CytoFLEX mosaic Spectral Detection Module will be installed in the ULS very soon. It allows seamless switching between true conventional and spectral modes, empower you to tackle even the most complex experiments with up to 63 detection channels, exquisite fluorescence sensitivity and unmatched flexibility for your spectral flow cytometry experiments.    In this seminar, the advantages of using Spectral Flow Cytometry and how it enhances multiparameter cellular analysis will be explored. You’ll be guided through a step-by-step overview—from panel design and sample preparation to data acquisition and analysis. Application examples to illustrate how Spectral Flow can be used to uncover deeper biological insights will be shown.    You are cordially invited to attend a seminar on the CytoFLEX S Flow Cytometer with the CytoFLEX mosaic Spectral Detection Module. Details are as follows:   Title: Introducing the CytoFLEX mosaic Detection Module Date: 24 Sept 2025 (Wednesday) 8 Oct 2025 (Wednesday) Time: 10:30 - 11:30 a.m. Speaker: Ms Susanna Li (Application Manager of Beckman Coulter Life Sciences) Venue: Y411   Should you have any enquiries, please contact Dr. Rachel Li/Dr. Ryan Chow.   All are welcome!

ULS Seminar - Introducing the CytoFLEX mosaic Detection Module

CytoFLEX S Flow Cytometer with the CytoFLEX mosaic Spectral Detection Module will be installed in the ULS very soon. It allows seamless switching between true conventional and spectral modes, empower you to tackle even the most complex experiments with up to 63 detection channels, exquisite fluorescence sensitivity and unmatched flexibility for your spectral flow cytometry experiments.   You are cordially invited to attend a seminar on the CytoFLEX S Flow Cytometer with the CytoFLEX mosaic Spectral Detection Module. Details are as follows:   Title: Introducing the CytoFLEX mosaic Detection Module Date: 24 Sept 2025 (Wednesday) Time: 10:30 - 12:00 Speaker: Ms Susanna Li (Application Manager of Beckman Coulter Life Sciences) Venue: Y411   Should you have any enquiries, please contact Dr. Rachel Li/Dr. Ryan Chow   All are welcome!

Visit by Ms Fang Zhou, Chairman of Ningbo Scientz Biotechnology Co., Ltd.

ULS Seminar - Introducing the THUNDER Imager Cell Spinning Disk from Leica

The University Research Facility in Life Sciences (ULS) is co-organizing a seminar on Spinning Disk Widefield/Confocal Microscope with Leica. This seminar will be focused on the new Thunder Spinning Disk Microscope which allows showcase its imaging capabilities and explore its potential applications in the current research workflows.   The details of the upcoming seminar are as follow:   Title: Introducing the New THUNDER Imager Cell Spinning Disk from Leica   Date: 5 Sep 2025 (Friday)   Time: 2:30  – 3:00 pm   Speaker:  Mr. Bob Tang, Application Specialist, Leica Microsystems   Webminar URL: https://polyu.hk/pmTYP (Microsoft Teams) Meeting ID: 238 147 933 985 7 Passcode: LQ7WE2rS   Brief introduction: Leica Thunder Spinning Disk Microscope is a confocal system with ultra-fast speed, low phototoxicity and the traditional pinhole crosstalk issue is resolved by Thunder technology. Recommended Applications of Spinning Disk Microscope: • Capture fast events such as calcium signalling (e.g., Fura-4F, GCaMP) and vesicle/RNA transport • Perform 3D confocal imaging of organoids, 3D tissue slide imaging, and long-term time-lapse studies Should you have any enquiries, please contact Dr. Idy Ho or Dr. Zhang Shuqi.    All are welcome!   Thank you for your attention.

ULS seminar - Enhanced Efficiency in EV Isolation Using the Automated EXODUS System

The University Research Facility in Life Sciences (ULS) is co-organizing a seminar on EXODUS Automatic EVs Isolation System with Cold Spring Biotech Corp. This seminar will be focused on the application of EXODUS, which simplifies EVs isolation, ensuring high purity and reproducibility across various sample types.   The details of the upcoming seminar are as follow:   Title: Enhanced Efficiency in EV Isolation Using the Automated EXODUS System   Date: 11 August 2025 (Monday)   Time: 15:00  – 16:00    Venue: Y715   Should you have any enquiries, please contact Dr. Ryan Chow.   All are welcome!   Thank you for your attention.

ULS Newsletter (13th Issue)

The 13th issue of the ULS newsletter has been issued. Please click the image below to view it online.   In this issue, we highlight a few pieces of new equipment, recent publications by our users, and introduce our animal MRI scanner for preclinical studies.   Thank you for your support.

ULS Seminar - 24 reasons to choose AVITI24

The University Research Facility in Life Sciences (ULS) is co-organizing a seminar on Next generation sequencing (NGS) with Medikonia. This seminar will be focused on the application of AVITI24, which integrates NGS and in situ multiomics.   The details of the upcoming seminar are as follow:   Title: 24 reasons to choose AVITI24   Date: 16 May 2025 (Fri)   Time: 11:00  – 12:00 pm    Venue: Y715   Should you have any enquiries, please contact Dr. Alan Leung or Dr. Ryan Chow.   All are welcome!   Thank you for your attention.  

ULS Seminar - Introducing the CytoFLEX platform and CytoFLEX mosaic module

The University Research Facility in Life Sciences (ULS) is co-organizing a seminar on flow cytometry with Beckman Coulter. This seminar will be focused on the new CytoFLEX module which allows seamless switching between the true conventional and spectral flow cytometry.    The details of the upcoming seminar are as follow:   Title: Introducing the CytoFLEX platform and CytoFLEX mosaic module   Date: 15 May 2025 (Thu)   Time: 10:30  – 11:30 am   Venue: Y303   Should you have any enquiries, please contact Dr. Rachel Li.   All are welcome!   Thank you for your attention.