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Vitrification refers to the formation of an amorphous solid that does little to no damage to the sample structure and is a critical technique for cellular and structural biology research where samples are cooled so rapidly that the surrounding water molecules do not have time to crystallize. Good vitrification is a crucial step in structural biology applications, such as single particle analysis (SPA), cryo-electron tomography (cryo-ET), and microcrystal electron diffraction (MicroED). The ThermoFisher Vitrobot Mark IV System allows users to perform the vitrification of samples in a precise and reproducible way, thereby ensuring high sample quality for subsequent cryo-EM and cryo-ET workflows.


Dr. Harvey Chan

Scientific Officer

Mr. Sirui Li

Assistant Scientific Officer

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