Chief Supervisor

Dr PAN Feng

Project Title

The effect of dopamine on the firing pattern of retinal ganglion cells in the myopic mouse retina

Synopsis

In the process of emmetropization, the retina plays an important role in the formation of myopia by transmitting information to the sclera.
Myopia is characterized by an elongated eye axis, and this process is thought to be regulated primarily by the retina. It is also suggested that dopamine plays a key role in myopia development.
To further understand the role of dopamine in the myopic defocus process, the firing patterns of retinal ganglion cells (RGCs) will be tested and compared in lens-induced myopia (LIM) mouse models using various transgenic mice, while wild-type mice will be used as a control. The firing characteristics of RGCs will be investigated using multielectrode array (MEA) and patch clamp methods.
This study is expected to explore the role of dopamine and its receptors on the firing pattern of RGCs in the retina.