- Y830
- +852 3400 8674
- clarence-tt.wong@polyu.edu.hk
ORCID ID
SCOPUS IDResearch Overview
My research group focuses on using state-of-the-art peptide and protein chemistries to manipulate biological systems, including (1) development of multifunctional antibodies for immunotherapy; (2) chemical manipulation of cell behaviour for cell-based therapeutic development; and (3) chemical modification of functional proteins for diseases detection and treatment.
Research Interests
Education and Academic Qualifications
- Bachelor of Science in Biochemistry, Department of Biochemistry, The Chinese University of Hong Kong
- Doctor of Philosophy in Biological Sciences, School of Biological Sciences, Nanyang Technological University, Singapore
Academic and Professional Experience
- Associate Director, PolyU-BGI Joint Research Centre for Genomics and Synthetic Biology in Global Ocean Resources (2025 - Present)
- Program Leader, Master of Science in Biopharmaceutical Development and Commercialization (2023 - Present)
Achievements
- Wong, C. T. T., Shao C. Peptidic Bispecific Antibody, Preparation and Application Thereof. 2022, US 63/269638. CN 202380036733.8 (PAT-1440-CN-PCT); EP 23773619.4(PAT-1440-EP-EPT); PCT/CN2023/080473(PAT-1440-WO-PCT)
- Li, X., Tung, C. L., and Wong, C. T. T. Compounds, compositions and methods for the preparation of peptide/protein conjugates. 2017, US9752137, 14727163.
- Shao, C.; Tang, B.; Chu, J. C. H.; Lau, K. M.; Wong, W.-T.; Che, C.-M.; Tai, W. C. S.; Wong, W.-T.; Wong, C. T. T. Macrophage-engaging peptidic bispecific antibodies (pBsAbs) for immunotherapy via a facile bioconjugation strategy. Chemical Science 2024, 15, 11272–11278, 10.1039/D4SC00851K. DOI: 10.1039/D4SC00851K
- Li, B.; Yuan, D.; Chen, H.; Wang, X.; Liang, Y.; Wong, C. T. T.; Xia, J. Site-selective antibody-lipid conjugates for surface functionalization of red blood cells and targeted drug delivery. Journal of Controlled Release 2024, 370, 302–309. DOI: https://doi.org/10.1016/j.jconrel.2024.04.038
- Xiong, J.; Chu, J. C. H.; Fong, W.-P.; Wong, C. T. T.; Ng, D. K. P. Specific Activation of Photosensitizer with Extrinsic Enzyme for Precisive Photodynamic Therapy. Journal of the American Chemical Society 2022, 144, 10647–10658. DOI: 10.1021/jacs.2c04017
- Chu, J. C. H.; Shao, C.; Ha, S. Y. Y.; Fong, W.-P.; Wong, C. T. T.; Ng, D. K. P. One-pot peptide cyclisation and surface modification of photosensitiser-loaded red blood cells for targeted photodynamic therapy. Biomaterials Science 2021, 9, 7832–7837, 10.1039/D1BM01306H. DOI: 10.1039/D1BM01306H
- Chu, J. C. H.; Fong, W.-P.; Wong, C. T. T.; Ng, D. K. P. Facile Synthesis of Cyclic Peptide–Phthalocyanine Conjugates for Epidermal Growth Factor Receptor-Targeted Photodynamic Therapy. Journal of Medicinal Chemistry 2021, 64, 2064–2076. DOI: 10.1021/acs.jmedchem.0c01677
