The Department of Applied Biology and Chemical Technology at the Hong Kong Polytechnic University (PolyU) has a long history of interdisciplinary research in chemistry and biology. From 2001 to 2009, with the strong support of the Hong Kong Research Grants Council, the Institute of Molecular Technology for Drug Discovery and Synthesis was established. At the end of 2010, the Partner State Key Laboratory of Chirosciences was approved by the Ministry of Science and Technology (MOST) to be established in PolyU as a partner laboratory of the State Key Laboratory of Bio-organic and Natural Products Chemistry in the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences. In mid-2011, the Partner State Key Laboratory of Chirosciences started to operate. In 2018, upon approval by MOST, the Partner State Key Laboratory of Chirosciences was renamed as the State Key Laboratory of Chemical Biology and Drug Discovery.