- Y824-06
- +852 3400 8867
- yangxian.yang@polyu.edu.hk
ORCID ID
SCOPUS IDResearch Overview
My research focuses on the biochemical and structural characterization of Shelterin Complex in Trypanosoma brucei, to elucidate how they maintain telomere integrity and regulate Variable Surface Glycoprotein (VSG) switching.
Research Interests
Education and Academic Qualifications
- Bachelor of Science, Hunan traditional Chinese medicine University
- Master of Science, Jinan University
- Doctor of Philosophy, The Hong Kong Polytechnic University
- Postdoctoral Fellow, The Hong Kong Polytechnic University
Achievements
- Gaurav, A. K.; Afrin, M.; Yang, X.; Saha, A.; Sayeed, S. K. A.; Pan, X.; Ji, Z.; Wong, K.-B.; Zhang, M.; Zhao, Y.; Li, B. The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression. Nature Communications 2023, 14, 1576.
DOI: 10.1038/s41467-023-37307-0 - Afrin, M.; Gaurav, A. K.; Yang, X.; Pan, X.; Zhao, Y.; Li, B. TbRAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing. Science Advances 2020, 6, eabc4065. DOI: 10.1126/sciadv.abc4065
- Yang, X.; Zhang, Y. B.; Wu, Z. N.; Zhang, X. Q.; Jiang, J. W.; Li, Y. L.; Wang, G. C. Six new prenylated acetophenone derivatives from the leaves of Acronychia oligophlebia. Fitoterapia 2015, 105, 156–159. DOI: 10.1016/j.fitote.2015.07.002
