- Y803
- +852 3400 8728
- vincent.keng@polyu.edu.hk
ORCID ID
SCOPUS IDResearch Overview
Our research group focuses on elucidating the genetic mechanisms of various types of human cancers. The information obtained will translate to better disease prevention, diagnosis and establishing effective therapeutic regimes
Research Interests
Education and Academic Qualifications
- Bachelor of Applied Science, Curtin University of Technology, Western Australia
- Master of Science, University of Western Australia
- Doctor of Philosophy, University of Fukui, Japan
Academic and Professional Experience
- Member, American Association for Cancer Research (AACR)
Achievements
- Pang, R.-K.; Shi, J.; Peng, X.-Y.; Su, S.; Zheng, J.-Y.; Le, K.; Keng, V. W.; Zhang, S.-J.; Li, X.-X. Huang-Lian-Jie-Du decoction alleviates cognitive deficits in Alzheimer’s disease model 5xFAD mice by inhibiting Trem2/Dap12 signaling pathway. Chinese Medicine 2025, 20, 50. DOI: 10.1186/s13020-025-01098-x
- Keng, V. W.; Su, S.; Chui, E. S. T.; To, J. C.; Zhang, Y. J.; Li, X. X. ANKRD17 induces pro-survival signaling pathways that enhance cellular invasion and migration during hepatocellular carcinoma tumorigenesis. iScience 2025, 28, 112463. DOI: 10.1016/j.isci.2025.112463
- Su, S.; Liu, T.; Zheng, J. Y.; Wu, H. C.; Keng, V. W.; Zhang, S. J.; Li, X. X. Huang Lian Jie Du decoction attenuated colitis via suppressing the macrophage Csf1r/Src pathway and modulating gut microbiota. Front Immunol 2024, 15, 1375781. DOI: 10.3389/fimmu.2024.1375781
- Cheung, L.-H.; To, J. C.; Wong, W.-K.; Stuart, M. C. A.; Kajitani, T.; Keng, V. W.; Leung, F. K.-C. Tailoring Multicontrolled Supramolecular Assemblies of Stiff-Stilbene Amphiphiles into Macroscopic Soft Scaffolds as Cell-Material Interfaces. ACS Applied Materials & Interfaces 2024, 16, 4056–4070. DOI: 10.1021/acsami.3c16795
- Zhang, X.; Shan, G.; Li, N.; Chen, J.; Ji, C.; Li, X.; Jiang, L.; Lee, T. K. W.; Keng, V. W.; Zhao, Y. An autophagy-inducing stapled peptide induces mitochondria dysfunction and triggers autotic cell death in triple-negative breast cancer. Cell Death Discovery 2023, 9, 303. DOI: 10.1038/s41420-023-01600-0
- To, J. C.; Gao, S.; Li, X. X.; Zhao, Y.; Keng, V. W. Sorafenib Resistance Contributed by IL7 and MAL2 in Hepatocellular Carcinoma Can Be Overcome by Autophagy-Inducing Stapled Peptides. Cancers (Basel) 2023, 15. DOI: 10.3390/cancers15215280
- Keng, V. W.; Chiu, A. P.; To, J. C.; Li, X.-X.; Linden, M. A.; Amin, K.; Moriarity, B. S.; Yusa, K. Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma. Heliyon 2023, 9, e18774. DOI: https://doi.org/10.1016/j.heliyon.2023.e18774
- Chen, J.; Zhang, X.; Gao, S.; Li, N.; Keng, V.; Zhao, Y. A Beclin 1-targeting stapled peptide synergizes with erlotinib to potently inhibit proliferation of non-small-cell lung cancer cells. Biochem Biophys Res Commun 2022, 636, 125–131. DOI: 10.1016/j.bbrc.2022.10.053
- To, J. C.; Chiu, A. P.; Tschida, B. R.; Lo, L. H.; Chiu, C. H.; Li, X.-X.; Kuka, T. P.; Linden, M. A.; Amin, K.; Chan, W.-C.; Bell, J. B.; Moriarity, B. S.; Largaespada, D. A.; Keng, V. W. ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis. JHEP Reports 2021, 3, 100223. DOI: https://doi.org/10.1016/j.jhepr.2020.100223
- Leung, H. W.; Leung, C. O. N.; Lau, E. Y.; Chung, K. P. S.; Mok, E. H.; Lei, M. M. L.; Leung, R. W. H.; Tong, M.; Keng, V. W.; Ma, C.; Zhao, Q.; Ng, I. O. L.; Ma, S.; Lee, T. K. EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma. Cancer Res 2021, 81, 3229–3240. DOI: 10.1158/0008-5472.Can-21-0184
- Lo L.H. & Keng V.W.* (2019) Transgenic Mice. In: Gu D., Dupre M. (eds) Encyclopedia of Gerontology and Population Aging. Springer, Cham. [https://doi.org/10.1007/978-3-319-69892-2]
