Chief Supervisor

Dr Ellen TAN

Project Title

Mechanistic Study on the Regulation of Neuroimmune Inflammation by Bioactive Polysaccharides from a Multi-Omics Perspective

Synopsis

Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system characterized primar ily by optic nerve and spinal cord damage. It manifests clinically as severe visual impairment, limb paralysis, and sensory deficits, with high relapse rates and significant disability. Current treatments rely on immunosuppressants and biologics, which still face limitations such as inadequate response and long-term side effects, highlighting the urgent need to develop safer and more effective intervention strategies.
This project employs integrated multi-omics analysis to systematically investigate the potential regulatory effects of natural bioactive polysaccharides on NMOSD. By utilizing multi-omics technologies, the study aims to elucidate the holistic modulatory impact and multi-target network of bioactive polysaccharides in NMOSD models. The findings are expected to provide new insights into the pathological mechanisms of the disease and lay a theoretical foundation for developing novel therapeutic strategies based on bioactive polysaccharides.