Chief Supervisor

Prof. HE Mingguang

Project Title

Synopsis

Myopia has become a widely recognized public health issue globally, with an increasing prevalence and severity, particularly among children and adolescents. Progressive axial elongation is a characteristic property and is associated with increasing myopia-associated complications such as retinal detachment, glaucoma, and pathological maculopathy. Effective interventions, including visual behavior management, optical correction, pharmacotherapy, and repeated low-level red light therapy, offer various options for slowing myopia progression. However, early and individualized treatment strategies are still needed to better control its advancement.

The biological mechanisms of eyeball growth regulation and intervention responses have not been completely understood, which, to some extent, limits the development of precise, individualized prevention and control strategies. With the advancement of visual electrophysiology, genetic analysis, and molecular biology, researchers have the opportunity to deeply reveal the changes in the retinal–choroidal microenvironment and signaling transduction pathways during the occurrence and intervention of myopia. The primary objective of this study is to integrate clinical research with mechanism exploration, which involves not only assessing the efficacy of the intervention bout also analyzing the underlying pathophysiological mechanisms, thereby promoting evidence-based and individualized strategies for the prevention and control of myopia.