Chief Supervisor

Prof. Henry CHAN

Project Title

Synopsis

Myopia is becoming more prevalent worldwide.The eye experiences dynamic growth throughout childhood period. Human myopia continues to develop and progress even when refractive errors were fully corrected, but the underlying biological mechanism is not fully understood.

Some recent studies suggested that long- and mid-wavelength sensitive cones (L/M ratio) is one of the determinants of myopia susceptibility.With electrophysiology studies, higher L/M cone ratio is suggested to be associated with lower occurrence of myopia. Epidemiological evidence supported that children with color vision deficiency (CVD), anticipated to have L/M ratio interrupted, had a lower rate of myopia. This relationship between L/M ratio and refractive error occurrence is attributed to longitudinal chromatic aberration, but some researchers suggested that the chromatic opponent theory may play a more important role. It implies that refractive development is a spectral sensitive and specific visually guided homeostatic modulation but it is not uniform across species.

This project aims to evaluate the effect of colour- correction as myopia control strategy on the changes of certain physiological responses related to myopia progression. Various myopiagenic stimulations will be applied to investigate the retinal activities highly associated with myopia development under different types of colour-correction strategy. The results from this study will help to understand how the chromatic opponent characteristics contribute to myopia development and progression. It also help to develop the new strategy for myopia control.