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Dr Leo Leung
PolyU Scholars Hub

Dr Leung Ka-kit, Leo

Research Assistant Professor

Research Overview

My research focuses on integrating behavioral and biological data to develop personalized, holistic mental health interventions. In collaboration with industrial partners, I am designing innovative and scalable methods—such as artistic and gamified experimental paradigms powered by AI—to measure cognitive and emotional responses. These responses include attention, emotional bias, strategic flexibility, and achievement, which facilitate expression detection and support counseling efforts.

To synthesize these diverse data streams, I am creating a knowledge management platform that visualizes complex interactions and enables inference at a system level. This integrated platform aims to uncover the underlying biological mechanisms of mental health conditions, including novel metabolic or signaling pathways, thereby supporting the development of precision medicine and nutrition strategies for personalized risk assessment and targeted interventions.

Education and Academic Qualifications

  • Bachelor of Engineering, The Chinese University of Hong Kong
  • Master of Philosophy, The Chinese University of Hong Kong
  • Master of Philosophy, The Chinese University of Hong Kong
  • Doctor of Philosophy, The Chinese University of Hong Kong

Research Interests

  • Mental health
  • Environmental Health and Toxicology
  • AI
  • Omics
  • Drugs and Chemicals

Achievements

  1. Leung RK, Cheng QX, Wu ZL, Khan G, Liu Y, Xia HY, Wang J. CRISPR-Cas12-based nucleic acids detection systems. Methods. 2022 Jul;203:276-281 
  2. Leung KK, Zhang R, Hashim MJ, Fang M, Xu J, Sun D, Li X, Liu Y, Deng H, Zeng D, Lin Z, He P, Zhang Y, Zhu X, Liang D, Xing A, Lee SS, Memish ZA, Jiang G, Khan G. Effectiveness of containment strategies in preventing SARS-CoV-2 transmission. J Infect Public Health. 2022 Jun;15(6):609-614. 
  3. Huang, C. et al. Genome-guided Investigation of Antibiotic Substances produced by Allosalinactinospora lopnorensis CA15-2(T) from Lop Nor region, China. Sci. Rep. 6, 20667 (2016). 
  4. Leung, R. K.-K. & Wu, Y.-K. Circulating microbial RNA and health. Sci. Rep. 5, 16814 (2015). 
  5. Cheng, R. et al. Virtual Pharmacist: A Platform for Pharmacogenomics. PLoS One 10, e0141105 (2015). 
  6. Chen, T. et al. Investigation of key interventions for shigellosis outbreak control in China. PLoS One 9, e95006 (2014). 
  7. Leung, R. K.-K. et al. Modulation of potential respiratory pathogens by pH1N1 viral infection. Clin. Microbiol. Infect. 19, 930–5 (2013). 
  8. Leung, R. K. K. et al. Using a multi-staged strategy based on machine learning and mathematical modeling to predict genotype-phenotype risk patterns in diabetic kidney disease: a prospective case-control cohort analysis. BMC Nephrol. 14, 162 (2013). 
  9. Li, S.-K. et al. Detection and identification of plasma bacterial and viral elements in HIV/AIDS patients in comparison to healthy adults. Clin. Microbiol. Infect. 18, 1126–33 (2012). 

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