助理教授（研究）
李燁博士
助理教授（研究）
BVetMed (ZJU), MPhil (UCAS), PhD (CUHK)
- ST524
- +852 2766 4842
- ye-julie.li@polyu.edu.hk
- 運動科學和肌肉骨骼健康
簡歷
李燁博士于香港中文大學獲得矯形外科及創傷學博士，此前先後在浙江大學和中國科學院大學獲得學士及碩士學位。她的研究主要集中於肌骨系統康復治療，特別是脈衝電磁場（PEMF）及運動干預對膝骨關節炎的康復治療。此外，其研究興趣亦涵蓋可穿戴設備和物理因數在肌骨康復中的應用，以及中藥與生物材料在肌肉骨骼疾病治療中的應用。
截至2026年7月，她已發表超過60篇論文（其中22篇影響因數大於10）、2部書籍章節，獲授權3項專利，Google Scholar H指數為23，她以主要申請人（PI）身份獲得包括國家自然科學基金、香港特區政府醫療衛生基金及企業橫向課題在內的多項研究資助，累計經費約300萬港幣；作為共同申請人（Co-I）參與專案經費合計約1300萬港幣。其研究成果曾榮獲中國細胞生物學會磁生物學大會最佳壁報獎、《骨科轉化醫學雜誌》高被引論文獎、紀念劉士豪-朱憲彝最佳論文獎及日內瓦發明獎等多項學術榮譽。
李博士是中國生物材料學會康復器械與生物材料分會委員和中國康復醫學會青年委員，于2025年獲頒國際華人骨研學會（ICMRS）終身會員。她還擔任《Journal of Orthopaedic Translation》期刊青年編委、國家自然科學基金委同行評議專家，以及多本學術同行評審期刊(Osteoarthritis and Cartilage、Collagen and Leather 、Phytomedicine、Pharmacological Research 、Journal of Orthopaedics Translation、Bioactive materials 、Biomaterials、Journal of Magnesium and Alloys、Chemical Engineering Journal 等 )的審稿人。李博士歡迎有志于肌骨康復領域的博士研究生加入團隊。
學歷
• Bachelor of Veterinary Medicine, Zhejiang University
• Master of Philosophy in Biomedical Engineering, University of Chinese Academy of Sciences
• Doctor of Philosophy in Orthopaedics and Traumatology, The Chinese University of Hong Kong
• Master of Philosophy in Biomedical Engineering, University of Chinese Academy of Sciences
• Doctor of Philosophy in Orthopaedics and Traumatology, The Chinese University of Hong Kong
研究興趣
研究成果
- Pang Q, Zhou R, Li Y (co-first author), et al. Elevated calcitonin gene-related peptide expression through prostaglandin E2-EP4 receptor pathway in promoting proliferative periosteum formation in primary hypertrophic osteoarthropathy. Journal of Orthopaedic Translation, 2026, 58: 101096.
- Jin R, Zhang J, Wang Y, et al. , Li Y(corresponding author), Wang D, Xue L. EZH2 in non-cancerous diseases: Expanding horizons. Protein & Cell, 2025: pwaf032.
- Cao S, Wei Y, Xiong A, Yue Y, Yang J, Wang D, Liu X, Zeng H, Shi D, Li Y(corresponding author), Paeonol inhibits ACSL4 to protect chondrocytes from ferroptosis and F ameliorates osteoarthritis progression, Journal of Orthopaedic Translation, 2025, 50: 1-13.
- Yao Z, Chen Z, He X, Wei Y, Qian J, Zong Q, He S, Song L, Ma L, Lin S, Li L, Xue L, Fu S, Zhang J., Li Y(corresponding author), D WANG. Bioactive MgO/MgCO3/Polycaprolactone Multi-gradient Fibers Facilitate Peripheral Nerve Regeneration by Regulating Schwann Cell Function and Activating Wingless/integrase-1 Signaling. Advanced Fiber Materials. 2025, 7(1): 315-337.
- Chen Z, Yao Z, Wu M, et al., Li Y(corresponding author), Xue L, Wang D. Epigenetic reprogramming via EZH2 inhibition rescues fibroadipose pathogenesis in secondary lymphedema through activating PPARγ signaling. Journal of Orthopaedic Translation, 2025, 55: 309-322.
- Fan T, Xia P, Ahmed S, Tsang Y, Yao Z, Wang D, Chen Z, Xue L, Shi D, Wang B, Cheung C, Pang Y, Li Y(corresponding author), Fu S. Wavelength-dependent photobiomodulation attenuates synovial inflammation in fibroblast-like synoviocytes and a collagenase-induced osteoarthritis model. Journal of Photochemistry and Photobiology B: Biology, 2025, 113276.
- Fan T, Xia P, Ahmed S, Tsang Y, Li Y(corresponding author), Fu S. Optimizing LED photobiomodulation parameters to prevent cartilage matrix degradation in knee osteoarthritis: in vitro and in vivo study. Journal of Orthopaedic Surgery and Research, 20(1), 933. 2025.
- Li Y, Xu J, Mi J, He X, Pan Q, Zheng L, Zu H, Chen Z, Dai B, Li X, Pang Q, Zou L, Zhou L, Huang L, Tong W, Li G, Qin L. Biodegradable magnesium combined with distraction osteogenesis synergistically stimulates bone tissue regeneration via CGRP-FAK-VEGF signaling axis. Biomaterials, 2021, 275: 120984.
- Li Y, Li L, Li Y (co-first author), Feng L, Wang B, Wang M, Wang H, Zhu M, Yang Y, Waldorff E, Zhang N, Viohl I, Lin S, Bian L, Lee W, Li G. Enhancing cartilage repair with optimized hydrogel-based scaffold with pulsed electromagnetic field. Bioactive Materials, 2023, 22: 312-324.
- Li Y, Pan Q, Xu J, Li G, Qin L. Overview of methods for enhancing bone regeneration in distraction osteogenesis: Potential roles of biometals. Journal of Orthopaedic Translation, 2021, 27: 110-118.
- Lai Y, Li Y (co-first author), Cao H, Long J, Wang X, Li L, Li C, Jia Q, Teng B, Tang T, Peng J, Eglin D, Alini M, Grijpma D, Richards G, Qin L. Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect. Biomaterials, 2019, 197: 207-219.
- Li Y, Chen SK, Li L, Qin L, Wang X, Lai Y. Bone defect animal models for testing efficacy of bone substitute biomaterials. Journal of Orthopaedic Translation, 2015, 3(3): 95-104.
- Chen B, Sun Y, Xu Z, et al. Li Y, et al. Motion Intention Recognition and DDPG-Based Adaptive Impedance Control for a Robotic Upper-Limb Exoskeleton[J]. IEEE transactions on neural systems and rehabilitation engineering: a publication of the IEEE Engineering in Medicine and Biology Society.
- Li X, Dai B, Guo J, Zhu Y, Xu J, Xu S, Yao Z, Chang L, Li Y, He X, Chow D, Zhang S, Yao H, Tong W, Ngai T, Qin L. Biosynthesized bandages carrying magnesium oxide nanoparticles induce cortical bone formation by modulating endogenous periosteal cells. ACS Nano, 2022.
- Yao Z, Yuan W, Xu J, Tong W, Mi J, Chow H, Ho P, Li Y, Yao H, Li X, Xu S, Guo J, Zhu Q, Bian L, Qin L. Magnesium‐encapsulated injectable hydrogel and 3D‐engineered polycaprolactone conduit facilitate peripheral nerve regeneration. Advanced Science, 2022: 2202102.
- Pang Q, Xu Y, Huang L, Li Y, Lin Y, Hou Y, Hung V, Qi X, Ni X, Li M, Jiang Y, Wang O, Xing X, Qin L, Xia W. Bone geometry, density, microstructure and biomechanical properties in the distal tibia in patients with primary hypertrophic osteoarthropathy assessed by second-generation HR-pQCT. Journal of Bone and Mineral Research, 2022, 37(3): 484-493.
- Dai B, Xu J, Li X, Huang L, Hopkins C, Wang H, Yao H, Mi J, Zheng L, Wang J, Tong W, Chow H, He X, Li Y, He X, Hu P, Chen Z, Zu H, Li Y, Yao Y, Jiang Q, Qin L. Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis. Nature Communication, 2022, 13(1): 1-17.
- Mi J, Xu J, Yao Z, Yao H, Li Y, He X, Dai B, Zou L, Tong W, Zhang X, Hu P, Ruan Y, Tang N, Guo X, Zhao J, He J, Qin L. Implantable electrical stimulation at dorsal root ganglions accelerates osteoporotic fracture healing via calcitonin gene-related peptide. Advance Science, 2022, 9(1): 2103005.
- He X, Li Y, Guo J, Xu J, Zu H, Huang L, Ong M, Yung S, Qin L. Biomaterials developed for facilitating healing outcome after anterior cruciate ligament reconstruction: Efficacy, surgical protocols, and assessments using preclinical animal models. Biomaterials, 2020: 120625.
- Xu J, Wang J, Chen X, Li Y, Mi J, Qin L. The effects of calcitonin gene-related peptide on bone homeostasis and regeneration. Current Osteoporosis Reports, 2020, 18(6): 621-632.
- Cao HJ, Zheng LZ, Wang N, Wang L, Li Y, Li D, Lai Y, Wang X, Qin L. Src blockage by siRNA inhibits VEGF-induced vascular hyperpermeability and osteoclast activity – An in vitro mechanism study for preventing destructive repair of osteonecrosis. Bone, 2015, 74: 58-68.
