助理教授（研究）
李烨博士
助理教授（研究）
BVetMed (ZJU), MPhil (UCAS), PhD (CUHK)
- ST524
- +852 2766 4842
- ye-julie.li@polyu.edu.hk
- 运动科学和肌肉骨骼健康
简历
李烨博士于香港中文大学获得矫形外科及创伤学博士，此前先后在浙江大学和中国科学院大学获得学士及硕士学位。她的研究主要集中于肌骨系统康复治疗，特别是脉冲电磁场（PEMF）及运动干预对膝骨关节炎的康复治疗。此外，其研究兴趣亦涵盖可穿戴设备和物理因子在肌骨康复中的应用，以及中药与生物材料在肌肉骨骼疾病治疗中的应用。
截至2026年7月，她已发表超过60篇论文（其中22篇影响因子大于10）、2部书籍章节，获授权3项专利，Google Scholar H指数为23，她以主要申请人（PI）身份获得包括国家自然科学基金、香港特区政府医疗卫生基金及企业横向课题在内的多项研究资助，累计经费约300万港币；作为共同申请人（Co-I）参与项目经费合计约1300万港币。其研究成果曾荣获中国细胞生物学会磁生物学大会最佳墙报奖、《骨科转化医学杂志》高被引论文奖、纪念刘士豪-朱宪彝最佳论文奖及日内瓦发明奖等多项学术荣誉。
李博士是中国生物材料学会康复器械与生物材料分会委员和中国康复医学会青年委员，于2025年获颁国际华人骨研学会（ICMRS）终身会员。她还担任《Journal of Orthopaedic Translation》期刊青年编委、国家自然科学基金委同行评议专家，以及多本学术同行评审期刊(Osteoarthritis and Cartilage、Collagen and Leather 、Phytomedicine、Pharmacological Research 、Journal of Orthopaedics Translation、Bioactive materials 、Biomaterials、Journal of Magnesium and Alloys、Chemical Engineering Journal 等 )的审稿人。李博士欢迎有志于肌骨康复领域的博士研究生加入团队。
学历
• Bachelor of Veterinary Medicine, Zhejiang University
• Master of Philosophy in Biomedical Engineering, University of Chinese Academy of Sciences
• Doctor of Philosophy in Orthopaedics and Traumatology, The Chinese University of Hong Kong
• Master of Philosophy in Biomedical Engineering, University of Chinese Academy of Sciences
• Doctor of Philosophy in Orthopaedics and Traumatology, The Chinese University of Hong Kong
研究兴趣
研究成果
- Pang Q, Zhou R, Li Y (co-first author), et al. Elevated calcitonin gene-related peptide expression through prostaglandin E2-EP4 receptor pathway in promoting proliferative periosteum formation in primary hypertrophic osteoarthropathy. Journal of Orthopaedic Translation, 2026, 58: 101096.
- Jin R, Zhang J, Wang Y, et al. , Li Y(corresponding author), Wang D, Xue L. EZH2 in non-cancerous diseases: Expanding horizons. Protein & Cell, 2025: pwaf032.
- Cao S, Wei Y, Xiong A, Yue Y, Yang J, Wang D, Liu X, Zeng H, Shi D, Li Y(corresponding author), Paeonol inhibits ACSL4 to protect chondrocytes from ferroptosis and F ameliorates osteoarthritis progression, Journal of Orthopaedic Translation, 2025, 50: 1-13.
- Yao Z, Chen Z, He X, Wei Y, Qian J, Zong Q, He S, Song L, Ma L, Lin S, Li L, Xue L, Fu S, Zhang J., Li Y(corresponding author), D WANG. Bioactive MgO/MgCO3/Polycaprolactone Multi-gradient Fibers Facilitate Peripheral Nerve Regeneration by Regulating Schwann Cell Function and Activating Wingless/integrase-1 Signaling. Advanced Fiber Materials. 2025, 7(1): 315-337.
- Chen Z, Yao Z, Wu M, et al., Li Y(corresponding author), Xue L, Wang D. Epigenetic reprogramming via EZH2 inhibition rescues fibroadipose pathogenesis in secondary lymphedema through activating PPARγ signaling. Journal of Orthopaedic Translation, 2025, 55: 309-322.
- Fan T, Xia P, Ahmed S, Tsang Y, Yao Z, Wang D, Chen Z, Xue L, Shi D, Wang B, Cheung C, Pang Y, Li Y(corresponding author), Fu S. Wavelength-dependent photobiomodulation attenuates synovial inflammation in fibroblast-like synoviocytes and a collagenase-induced osteoarthritis model. Journal of Photochemistry and Photobiology B: Biology, 2025, 113276.
- Fan T, Xia P, Ahmed S, Tsang Y, Li Y(corresponding author), Fu S. Optimizing LED photobiomodulation parameters to prevent cartilage matrix degradation in knee osteoarthritis: in vitro and in vivo study. Journal of Orthopaedic Surgery and Research, 20(1), 933. 2025.
- Li Y, Xu J, Mi J, He X, Pan Q, Zheng L, Zu H, Chen Z, Dai B, Li X, Pang Q, Zou L, Zhou L, Huang L, Tong W, Li G, Qin L. Biodegradable magnesium combined with distraction osteogenesis synergistically stimulates bone tissue regeneration via CGRP-FAK-VEGF signaling axis. Biomaterials, 2021, 275: 120984.
- Li Y, Li L, Li Y (co-first author), Feng L, Wang B, Wang M, Wang H, Zhu M, Yang Y, Waldorff E, Zhang N, Viohl I, Lin S, Bian L, Lee W, Li G. Enhancing cartilage repair with optimized hydrogel-based scaffold with pulsed electromagnetic field. Bioactive Materials, 2023, 22: 312-324.
- Li Y, Pan Q, Xu J, Li G, Qin L. Overview of methods for enhancing bone regeneration in distraction osteogenesis: Potential roles of biometals. Journal of Orthopaedic Translation, 2021, 27: 110-118.
- Lai Y, Li Y (co-first author), Cao H, Long J, Wang X, Li L, Li C, Jia Q, Teng B, Tang T, Peng J, Eglin D, Alini M, Grijpma D, Richards G, Qin L. Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect. Biomaterials, 2019, 197: 207-219.
- Li Y, Chen SK, Li L, Qin L, Wang X, Lai Y. Bone defect animal models for testing efficacy of bone substitute biomaterials. Journal of Orthopaedic Translation, 2015, 3(3): 95-104.
- Chen B, Sun Y, Xu Z, et al. Li Y, et al. Motion Intention Recognition and DDPG-Based Adaptive Impedance Control for a Robotic Upper-Limb Exoskeleton[J]. IEEE transactions on neural systems and rehabilitation engineering: a publication of the IEEE Engineering in Medicine and Biology Society.
- Li X, Dai B, Guo J, Zhu Y, Xu J, Xu S, Yao Z, Chang L, Li Y, He X, Chow D, Zhang S, Yao H, Tong W, Ngai T, Qin L. Biosynthesized bandages carrying magnesium oxide nanoparticles induce cortical bone formation by modulating endogenous periosteal cells. ACS Nano, 2022.
- Yao Z, Yuan W, Xu J, Tong W, Mi J, Chow H, Ho P, Li Y, Yao H, Li X, Xu S, Guo J, Zhu Q, Bian L, Qin L. Magnesium‐encapsulated injectable hydrogel and 3D‐engineered polycaprolactone conduit facilitate peripheral nerve regeneration. Advanced Science, 2022: 2202102.
- Pang Q, Xu Y, Huang L, Li Y, Lin Y, Hou Y, Hung V, Qi X, Ni X, Li M, Jiang Y, Wang O, Xing X, Qin L, Xia W. Bone geometry, density, microstructure and biomechanical properties in the distal tibia in patients with primary hypertrophic osteoarthropathy assessed by second-generation HR-pQCT. Journal of Bone and Mineral Research, 2022, 37(3): 484-493.
- Dai B, Xu J, Li X, Huang L, Hopkins C, Wang H, Yao H, Mi J, Zheng L, Wang J, Tong W, Chow H, He X, Li Y, He X, Hu P, Chen Z, Zu H, Li Y, Yao Y, Jiang Q, Qin L. Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis. Nature Communication, 2022, 13(1): 1-17.
- Mi J, Xu J, Yao Z, Yao H, Li Y, He X, Dai B, Zou L, Tong W, Zhang X, Hu P, Ruan Y, Tang N, Guo X, Zhao J, He J, Qin L. Implantable electrical stimulation at dorsal root ganglions accelerates osteoporotic fracture healing via calcitonin gene-related peptide. Advance Science, 2022, 9(1): 2103005.
- He X, Li Y, Guo J, Xu J, Zu H, Huang L, Ong M, Yung S, Qin L. Biomaterials developed for facilitating healing outcome after anterior cruciate ligament reconstruction: Efficacy, surgical protocols, and assessments using preclinical animal models. Biomaterials, 2020: 120625.
- Xu J, Wang J, Chen X, Li Y, Mi J, Qin L. The effects of calcitonin gene-related peptide on bone homeostasis and regeneration. Current Osteoporosis Reports, 2020, 18(6): 621-632.
- Cao HJ, Zheng LZ, Wang N, Wang L, Li Y, Li D, Lai Y, Wang X, Qin L. Src blockage by siRNA inhibits VEGF-induced vascular hyperpermeability and osteoclast activity – An in vitro mechanism study for preventing destructive repair of osteonecrosis. Bone, 2015, 74: 58-68.
