教學人員
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- Sonata.Yau@polyu.edu.hk
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SCOPUS ID簡歷
邱淑瑜教授現任香港理工大學康復治療科學系副教授。她于香港科技大學獲得生物化學學士學位，並于香港大學李嘉誠醫學院取得神經科學博士學位。在加入理大擔任助理教授之前，邱教授曾先後獲得香港大學及加拿大健康研究院頒發的博士後研究獎學金。此後，她赴史丹福大學進行學術訪問，深入探索與神經老化相關的機制。
邱教授的神經生物學研究聚焦於精神疾病的細胞與分子機理，涵蓋抑鬱、焦慮及自閉症等領域。她在動物模型研究方面經驗豐富，致力於揭示慢性壓力與空氣污染物等環境因素如何調控神經可塑性，進而影響情緒與記憶形成。她的工作同時探索治療干預的潛在靶點，包括體能運動及中醫藥，並特別關注外周器官與大腦間的交互作用，以期推遲神經退化病變。
邱教授已發表超過90篇研究論文與綜述、4部書籍章節，並持有與藥物研發相關的專利。其成果多見於《Molecular Psychiatry》、《PNAS》、《Neurobiology of Disease》、《Molecular Neurobiology》等國際權威期刊。截至2026年1月，其Google Scholar H指數為35。邱教授亦于2022年獲Expertscape認可，位列脂聯素（adiponectin）研究領域全球前1%的專家。
學歷
- 香港科技大學生物化學系
- 香港大學解剖學系
研究興趣
- Cheng T, Formolo DA, Zhong YX, Ma ZH, Yu JS, Akhlaq H, Formolo NPS, Zhang L, Cheng KKY, Kranz G, Lin KG, Chen G, Siu P, Yoo JS, Lai CSW, Xu AM, So KF, Yau SY#. (2025) Rapid antidepressant effect of single-bout exercise is mediated by adiponectin-induced APPL1 nucleus translocation in anterior cingulate cortex. Molecular Psychiatry Dec;30(12):5760-5776. doi: 10.1038/s41380-025-03317-1. Covered by social medias including PsyPost https://www.psypost.org/scientists-identify-a-fat-derived-hormone-that-drives-the-mood-benefits-of-exercise/
- We ZJ, Yin Y, Liu RY, Li XH, Wang ZY, Wu CY, Tan JW, Fu ZZ, Song CH, Wong NL, Peng XY, Lai SX, Cui JH, Han MZ, Peng YH, Sun Y, Wu L, Aszic M, Zeng Li, Zhang HL, Yau SY#, Chen Gang# (2025) Chronic treatment of mixture of two iridoids proportional to prescriptional dose of Yueju improves hippocampal PACAP-related neuroinflammation and neuroplasticity signaling in the LPS-induced depression model. J Ethnopharmacology 2025 Feb 10;338(Pt 2):119031.
- Guo HH, Ou HN, Yu JS, Macedo JR, Formolo D, Cheng T, Yau SY#, Tsang HWH# (2025) Adiponectin as the potential mediator of pro-cognitive effects of physical exercise on Alzheimer’s disease. Neural Regeneration Research 21(1):96-106.
- Formolo DA; Yu JS; Lin KG; Tsang HWH; Ou HN; Kranz GS; Yau SY# (2023) Leveraging the Glymphatic and Meningeal Lymphatic Systems as Therapeutic strategies in Alzheimer’s Disease: An Updated Overview of Nonpharmacological Therapies. Molecular Neurodegeneration 18 (26)
- Recchia F, Leung CK, Chin EC, Fong DY, Montero D, Cheng CP, Yau SY, Siu PM (2022) Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: a systematic review and network meta-analysis of randomised controlled trials. British Journal of Sports Medicine 2022;0:1–7. doi:10.1136/bjsports-2022-105964
- Ahadullah*, Yau SY*#, Liu HX, TMC Lee, H Guo#, CCH Chan (2021) PM2.5 as a potential risk factor for Autism Spectrum Disorders: its possible link to neuroinflammation, oxidative stress and changes of gene expression. Neuroscience and Biobehavioral Reviews. Jun 30;128:534-548. doi: 10.1016/j.neubiorev.2021.06.043.
- Lee THY, Ahadullah, Christie BR, Lin KG, Siu PMF, Zhang L, Yuen TF, Komal P, Aimin Xu AM, Kwok-fai So KF, Yau SY# (2021) Chronic AdipoRon treatment mimics the effects of physical exercise on restoring hippocampal neuroplasticity in diabetic mice. Molecular Neurobiology 58(9), 4666-4681 doi: 10.1007/s12035-021-02441-7
- Yau SY, Bettio L, Vetrici M, Truesdell A, Chiu C, Chiu J, Truesdell E, Christie BR. (2018) Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice. Neurobiology of Disease. 2018 Jan 29;113:11-22
- Yau SY, Bostrom C, Chiu J, Ghilan M, Chiu CY, Hryciw BN, Eadie BD, Christie BR. (2016) Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice. Neurobiology of Disease 19 (96):261-270
- Yau SY, Li A, Loo R, Ching YP, Christie BR, Lee TMC, Xu AM, So KF. (2014) Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. PNAS. 111 (44): 15810-15815 (Highlighted by Nature Reviews Neuroscience: Volume 15, Dec 2014; Nature Reviews Endocrinology: Nov 2014)
