教学人员
- QT504
- +852 2766 4890
- Sonata.Yau@polyu.edu.hk
- Personal Website
ORCID ID
SCOPUS ID简历
邱淑瑜教授现任香港理工大学康复治疗科学系副教授。她于香港科技大学获得生物化学学士学位，并于香港大学李嘉诚医学院取得神经科学博士学位。在加入理大担任助理教授之前，邱教授曾先后获得香港大学及加拿大健康研究院颁发的博士后研究奖学金。此后，她赴史丹福大学进行学术访问，深入探索与神经老化相关的机制。
邱教授的神经生物学研究聚焦于精神疾病的细胞与分子机理，涵盖抑郁、焦虑及自闭症等领域。她在动物模型研究方面经验丰富，致力于揭示慢性压力与空气污染物等环境因素如何调控神经可塑性，进而影响情绪与记忆形成。她的工作同时探索治疗干预的潜在靶点，包括体能运动及中医药，并特别关注外周器官与大脑间的交互作用，以期推迟神经退化病变。
邱教授已发表超过90篇研究论文与综述、4部书籍章节，并持有与药物研发相关的专利。其成果多见于《Molecular Psychiatry》、《PNAS》、《Neurobiology of Disease》、《Molecular Neurobiology》等国际权威期刊。截至2026年1月，其Google Scholar H指数为35。邱教授亦于2022年获Expertscape认可，位列脂联素（adiponectin）研究领域全球前1%的专家。
学历
- 香港科技大学生物化学系
- 香港大学解剖学系
研究兴趣
研究成果
- Cheng T, Formolo DA, Zhong YX, Ma ZH, Yu JS, Akhlaq H, Formolo NPS, Zhang L, Cheng KKY, Kranz G, Lin KG, Chen G, Siu P, Yoo JS, Lai CSW, Xu AM, So KF, Yau SY#. (2025) Rapid antidepressant effect of single-bout exercise is mediated by adiponectin-induced APPL1 nucleus translocation in anterior cingulate cortex. Molecular Psychiatry Dec;30(12):5760-5776. doi: 10.1038/s41380-025-03317-1. Covered by social medias including PsyPost https://www.psypost.org/scientists-identify-a-fat-derived-hormone-that-drives-the-mood-benefits-of-exercise/
- We ZJ, Yin Y, Liu RY, Li XH, Wang ZY, Wu CY, Tan JW, Fu ZZ, Song CH, Wong NL, Peng XY, Lai SX, Cui JH, Han MZ, Peng YH, Sun Y, Wu L, Aszic M, Zeng Li, Zhang HL, Yau SY#, Chen Gang# (2025) Chronic treatment of mixture of two iridoids proportional to prescriptional dose of Yueju improves hippocampal PACAP-related neuroinflammation and neuroplasticity signaling in the LPS-induced depression model. J Ethnopharmacology 2025 Feb 10;338(Pt 2):119031.
- Guo HH, Ou HN, Yu JS, Macedo JR, Formolo D, Cheng T, Yau SY#, Tsang HWH# (2025) Adiponectin as the potential mediator of pro-cognitive effects of physical exercise on Alzheimer’s disease. Neural Regeneration Research 21(1):96-106.
- Formolo DA; Yu JS; Lin KG; Tsang HWH; Ou HN; Kranz GS; Yau SY# (2023) Leveraging the Glymphatic and Meningeal Lymphatic Systems as Therapeutic strategies in Alzheimer’s Disease: An Updated Overview of Nonpharmacological Therapies. Molecular Neurodegeneration 18 (26)
- Recchia F, Leung CK, Chin EC, Fong DY, Montero D, Cheng CP, Yau SY, Siu PM (2022) Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: a systematic review and network meta-analysis of randomised controlled trials. British Journal of Sports Medicine 2022;0:1–7. doi:10.1136/bjsports-2022-105964
- Ahadullah*, Yau SY*#, Liu HX, TMC Lee, H Guo#, CCH Chan (2021) PM2.5 as a potential risk factor for Autism Spectrum Disorders: its possible link to neuroinflammation, oxidative stress and changes of gene expression. Neuroscience and Biobehavioral Reviews. Jun 30;128:534-548. doi: 10.1016/j.neubiorev.2021.06.043.
- Lee THY, Ahadullah, Christie BR, Lin KG, Siu PMF, Zhang L, Yuen TF, Komal P, Aimin Xu AM, Kwok-fai So KF, Yau SY# (2021) Chronic AdipoRon treatment mimics the effects of physical exercise on restoring hippocampal neuroplasticity in diabetic mice. Molecular Neurobiology 58(9), 4666-4681 doi: 10.1007/s12035-021-02441-7
- Yau SY, Bettio L, Vetrici M, Truesdell A, Chiu C, Chiu J, Truesdell E, Christie BR. (2018) Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice. Neurobiology of Disease. 2018 Jan 29;113:11-22
- Yau SY, Bostrom C, Chiu J, Ghilan M, Chiu CY, Hryciw BN, Eadie BD, Christie BR. (2016) Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice. Neurobiology of Disease 19 (96):261-270
- Yau SY, Li A, Loo R, Ching YP, Christie BR, Lee TMC, Xu AM, So KF. (2014) Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. PNAS. 111 (44): 15810-15815 (Highlighted by Nature Reviews Neuroscience: Volume 15, Dec 2014; Nature Reviews Endocrinology: Nov 2014)
