Academic Staff
- QT504
- +852 2766 4890
- sonata.yau@polyu.edu.hk
- Personal website
Biography
Prof. Sonata Suk-yu Yau is an Associate Professor in the Department of Rehabilitation Sciences at The Hong Kong Polytechnic University (PolyU). She earned her Bachelor's degree in Biochemistry from The Hong Kong University of Science and Technology and completed her Ph.D. in Neuroscience at the LKS Faculty of Medicine, The University of Hong Kong (HKU). Prior to joining PolyU as an Assistant Professor, Prof. Yau received postdoctoral training through research fellowships funded by HKU and the Canadian Institutes of Health Research. She further expanded her research experience during a sabbatical at Stanford University, where she investigated mechanisms of ageing-associated synaptic loss.
Prof. Yau has broad training in the cellular and molecular neurobiology of psychiatric disorders, including depression, anxiety, and autism. She has extensive experience using animal models to investigate how environmental factors, such as chronic stress and air pollutants, modulate neural plasticity, affecting mood and memory formation. Her research also explores therapeutic treatment targets, including physical exercise and Traditional Chinese Medicine (TCM), to mitigate neurodegeneration, with a special emphasis on the crosstalk between peripheral organs and the brain.
Prof. Yau has published over 90 research articles and reviews, four book chapters, and holds patent in drug discovery. She has published in Molecular Psychiatry, PNAS, Neurobiology of Disease, Molecular Neurobiology and etc, with an H-index of 35 (Google Scholar Jan 2026). She is recognized as an Expertscape Expert (2022), ranking top 1% scholar in adiponectin research.
Education and Academic Qualifications
- Bachelor of Science in Biochemistry, The Hong Kong University of Science and Technology
- Doctor of Philosophy, The University of Hong Kong
Research Interests
Research Output
- Cheng T, Formolo DA, Zhong YX, Ma ZH, Yu JS, Akhlaq H, Formolo NPS, Zhang L, Cheng KKY, Kranz G, Lin KG, Chen G, Siu P, Yoo JS, Lai CSW, Xu AM, So KF, Yau SY#. (2025) Rapid antidepressant effect of single-bout exercise is mediated by adiponectin-induced APPL1 nucleus translocation in anterior cingulate cortex. Molecular Psychiatry Dec;30(12):5760-5776. doi: 10.1038/s41380-025-03317-1. Covered by social medias including PsyPost https://www.psypost.org/scientists-identify-a-fat-derived-hormone-that-drives-the-mood-benefits-of-exercise/
- We ZJ, Yin Y, Liu RY, Li XH, Wang ZY, Wu CY, Tan JW, Fu ZZ, Song CH, Wong NL, Peng XY, Lai SX, Cui JH, Han MZ, Peng YH, Sun Y, Wu L, Aszic M, Zeng Li, Zhang HL, Yau SY#, Chen Gang# (2025) Chronic treatment of mixture of two iridoids proportional to prescriptional dose of Yueju improves hippocampal PACAP-related neuroinflammation and neuroplasticity signaling in the LPS-induced depression model. J Ethnopharmacology 2025 Feb 10;338(Pt 2):119031.
- Guo HH, Ou HN, Yu JS, Macedo JR, Formolo D, Cheng T, Yau SY#, Tsang HWH# (2025) Adiponectin as the potential mediator of pro-cognitive effects of physical exercise on Alzheimer’s disease. Neural Regeneration Research 21(1):96-106.
- Formolo DA; Yu JS; Lin KG; Tsang HWH; Ou HN; Kranz GS; Yau SY# (2023) Leveraging the Glymphatic and Meningeal Lymphatic Systems as Therapeutic strategies in Alzheimer’s Disease: An Updated Overview of Nonpharmacological Therapies. Molecular Neurodegeneration 18 (26)
- Recchia F, Leung CK, Chin EC, Fong DY, Montero D, Cheng CP, Yau SY, Siu PM (2022) Comparative effectiveness of exercise, antidepressants and their combination in treating non-severe depression: a systematic review and network meta-analysis of randomised controlled trials. British Journal of Sports Medicine 2022;0:1–7. doi:10.1136/bjsports-2022-105964
- Ahadullah*, Yau SY*#, Liu HX, TMC Lee, H Guo#, CCH Chan (2021) PM2.5 as a potential risk factor for Autism Spectrum Disorders: its possible link to neuroinflammation, oxidative stress and changes of gene expression. Neuroscience and Biobehavioral Reviews. Jun 30;128:534-548. doi: 10.1016/j.neubiorev.2021.06.043.
- Lee THY, Ahadullah, Christie BR, Lin KG, Siu PMF, Zhang L, Yuen TF, Komal P, Aimin Xu AM, Kwok-fai So KF, Yau SY# (2021) Chronic AdipoRon treatment mimics the effects of physical exercise on restoring hippocampal neuroplasticity in diabetic mice. Molecular Neurobiology 58(9), 4666-4681 doi: 10.1007/s12035-021-02441-7
- Yau SY, Bettio L, Vetrici M, Truesdell A, Chiu C, Chiu J, Truesdell E, Christie BR. (2018) Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice. Neurobiology of Disease. 2018 Jan 29;113:11-22
- Yau SY, Bostrom C, Chiu J, Ghilan M, Chiu CY, Hryciw BN, Eadie BD, Christie BR. (2016) Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice. Neurobiology of Disease 19 (96):261-270
- Yau SY, Li A, Loo R, Ching YP, Christie BR, Lee TMC, Xu AM, So KF. (2014) Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. PNAS. 111 (44): 15810-15815 (Highlighted by Nature Reviews Neuroscience: Volume 15, Dec 2014; Nature Reviews Endocrinology: Nov 2014)