Prof. Sonata YAU, Member of the Mental Health Research Centre (MHRC) and Associate Professor in the Department of Rehabilitation Sciences at The Hong Kong Polytechnic University, has uncovered the neural mechanism behind the rapid antidepressant effect of a single bout of physical exercise.
Her team found that just one 30-minute treadmill running at intermediate intensity could rapidly elevate mood in university student participants. Mechanistic evidence from animal models revealed that this effect is mediated by the activation of specific glutamatergic neurons in the anterior cingulate cortex (ACC)—a key brain region for emotion regulation—via the hormone adiponectin, which triggers nuclear translocation of the adaptor protein APPL1. This cascade enhances synaptic protein expression and spine formation through epigenetic regulation, leading to immediate relief of depressive symptoms. These findings highlight the powerful potential of physical exercise as a practical and accessible intervention for managing mood disturbances in young adults. Crucially, the research suggests that prompt physical exercise can help prevent the worsening of depressive mood, serving as an effective preventative measure against depression and supporting mental well-being in this population.
The study provides robust scientific evidence for the rapid antidepressant effects of physical exercise, paving the way for immediate rehabilitation strategies for depressive mood. This work has been recently published in Molecular Psychiatry, a leading journal in Psychiatry and Neuroscience Research.
Read the full paper: https://www.nature.com/articles/s41380-025-03317-1
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| Research Units | Mental Health Research Centre |
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