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Hollow Silica Nanostructures with Ultrasound Technology Offer a Less Invasive and Precise Treatment Alternative for Parkinson's Disease Patients

10 Jul 2026

Prof. Lei SUN, Professor of the Department of Biomedical Engineering at The Hong Kong Polytechnic University, and his research team introduced a cutting-edge approach combining ultrasound brain stimulation with hollow silica nanostructures (HSN), offering a safer, more precise, and more durable solution that brings new hope to Parkinson's disease patients with limited treatment options.

Parkinson’s disease (PD) has long been regarded as an irreversible condition among older adults. Although existing treatments may manage symptoms, they are often invasive or limited in precision and effectiveness.

In a recently published study on Nature Communications, Prof. Lei SUN, Professor of the Department of Biomedical Engineering at PolyU, and his research team addressed the need for neuromodulation approaches that are both precise and less invasive by combining low-intensity ultrasound with engineered hollow silica nanostructures (HSN) to achieve chronic, localised brain stimulation in mice, as well as therapeutic benefit in PD models.

This study provides a compelling proof of concept for chronic, localised and minimally invasive neuromodulation using ultrasound and HSN. This research offers a more precise, safer and durable solution that brings new hope to patients with limited treatment options.

Find more details in the full article on Innovation Digest: https://polyu.hk/aXfeL


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