Prof. Nathanael JIN Ling’s study reveals public health risks of drug-resistant Candida in cities

Prof. Nathanael JIN Ling, Member of the Research Institute for Future Food (RiFood), the Research Institute for Sustainable Urban Development (RISUD) and the Mental Health Research Centre (MHRC), and Assistant Professor in the Department of Civil and Environmental Engineering and the Department of Health Technology and Informatics, has recently published a pioneering research in Environmental Science & Technology Letters, shedding light on the public health risks posed by airborne Candida species in densely populated urban areas.

The key findings of the study are as follows:

• Drug-Resistant Candida in Urban Air: The study detected viable, drug-resistant strains of Candida parapsilosis, Candida albicans, and Candida tropicalis in city air samples—strains that were notably absent in coastal environments.

• Genetic Similarity to Clinical Strains: Airborne isolates exhibited a high degree of genetic similarity to those found in clinical settings, suggesting that community-acquired infections could occur through inhalation or skin contact.

• Multidrug Resistance: Of particular concern was the discovery of multidrug resistance in C. parapsilosis, raising questions about the role of urban pollution and climate change in driving antifungal resistance.

Candida species are classified as WHO fungal priority pathogens due to their severe health impacts.  Prof. Jin’s research highlights the urgent need to recognise urban air as a significant medium for the spread of antifungal-resistant strains.  Looking ahead, his research team plans to expand their work to larger, multi-site studies to better understand fungal transmission pathways, investigate urban reservoirs of drug-resistant fungi and strengthen One Health approach to combat the global threat of fungal resistance.