Chief Supervisor

Prof. PAN Feng

Project Title

Synopsis

This project investigates the role of red light in modulating the encoding properties of retinal α ganglion cells (RGCs) under both normal and myopic conditions. Using lens-induced and form-deprivation myopia models, the study will evaluate how different intensities of 650 nm red light influence neuronal signaling, including spike activities, excitatory and inhibitory postsynaptic currents, and membrane capacitance. In vitro retinal stretching will be employed to mimic axial elongation, while Cx36 knockout mice will serve as a control to assess the role of gap junctions in retinal circuitry. Electrophysiology and imaging methods will be applied to quantify changes in biophysical properties under focused and defocused stimuli. Findings are expected to provide new insights into how red light alters retinal signal processing and may contribute to the development of therapeutic strategies for myopia control.