Academic Staff
- GH176
- +852 3400 8880
- miao.xie@polyu.edu.hk
ORCID ID
SCOPUS IDResearch Overview
Dr Xie’s research focuses on antimicrobial resistance, transmission mechanisms, epidemiology, virulence and pathogenesis of important bacterial pathogens, and development of novel therapies against bacterial infections.
Education and Academic Qualifications
- Bachelor of Agriculture in Animal Science, Nanjing Agricultural University
- Master of Agriculture in Animal Nutrition and Feed Science, Nanjing Agricultural University
Academic and Professional Experience
Postdoctoral Fellow, The Hong Kong Polytechnic University
Research Interests
Research Output
- Xie M, Zhang Y, Chen K, Dong N, Zhou H, Huang Y, Liu C, Chan EWC, Chen S, & Zhang R. (2025). Increasing polymyxin resistance in clinical carbapenem-resistant Klebsiella pneumoniae strains in China between 2000 and 2023. Communications Medicine, 5(1), 73.
- Xie M, Chen K, Heng H, Chan EWC, & Chen S. (2025). Antimicrobial effect of sulconazole in combination with glucose/trehalose against carbapenem-resistant hypervirulent Klebsiella pneumoniae persisters. Microbiological Research, 292, 128006.
- Xie M, Ye L, Chen K, Xu Q, Yang C, Chen X, Chan EWC, Li F, Chen S. (2024). Clinical use of tigecycline may contribute to the widespread dissemination of carbapenem-resistant hypervirulent Klebsiella pneumoniae strains. Emerging Microbes & Infections, 2306957.
- Ma L#, Xie M#, Yang Y, Ding X, Li Y, Yan Z, Chan EWC, Chen S, Chen G, & Zhang R. (2024). Prevalence and genomic characterization of clinical Escherichia coli strains that harbor the plasmid-borne tet(X4) gene in China. Microbiological Research, 285, 127730.
- Chen K#, Xie M#, Dong N, Chan EWC, Zhang R, Chen S. (2023). Deciphering the underlying mechanisms mediating the transmission of blaNDM gene from human to animals: A genomics study of bacterial isolates from various sources in China, 2015 to 2017. Eurosurveillance, 28(37), p.2200925.
- Chen K#, Xie M#, Wang H, Chan EWC, Chen S. (2023). Intercontinental spread and clonal expansion of ColRNA1 plasmid-bearing Salmonella Corvallis ST1541 strains: a genomic epidemiological study. One Health Advances, 1(1), 1-15.
- Xie M, Chen K, Chan EWC, Zhang R, Chen S. (2022). Characterisation of clinical carbapenem-resistant K1 Klebsiella quasipneumoniae subsp. similipneumoniae strains harbouring a virulence plasmid. International Journal of Antimicrobial Agents, 60(2), 106628.
- Xie M, Chen K, Chan EWC, Chen S. (2022). Identification and genetic characterization of two conjugative plasmids that confer azithromycin resistance in Salmonella. Emerging Microbes & Infections, 11(1), 1049-1057.
- Xie M, Chen K, Chan EWC, Chen S. (2022). Synergistic Antimicrobial Effect of Colistin in Combination with Econazole against Multidrug-Resistant Acinetobacter baumannii and Its Persisters. Microbiology Spectrum, e00937-22.
- Xie M, Yang X, Xu Q, Ye L, Chen K, Zheng Z, Dong N, Sun Q, Shu L, Gu D, Chan EWC, Zhang R, Chen S. (2021). Clinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae. Communications Biology, 4(1), 1-9.
- Xie M, Chen K, Ye L, Yang X, Xu Q, Yang C, Dong N, Chan EWC, Sun Q, Shu L, Gu D, Lin X, Zhang R, Chen S. (2020). Conjugation of virulence plasmid in clinical Klebsiella pneumoniae strains through formation of a fusion plasmid. Advanced biosystems, 4(4), 1900239.
- Li R#, Xie M#, Liu L, Huang Y, Wu X, Wang Z, Chan EWC, Chen S. (2020). Characterisation of a cointegrate plasmid harbouring blaNDM-1 in a clinical Salmonella Lomita strain. International Journal of Antimicrobial Agents, 55(1), 105817.
- Xie M, Li R, Liu Z, Chan EWC, Chen S. (2018). Recombination of plasmids in a carbapenem-resistant NDM-5-producing clinical Escherichia coli isolate. Journal of Antimicrobial Chemotherapy, 73(5), 1230-1234.
- Li R#, Xie M#, Lv J, Wai-Chi Chan E, Chen S. (2017). Complete genetic analysis of plasmids carrying mcr-1 and other resistance genes in an Escherichia coli isolate of animal origin. Journal of Antimicrobial Chemotherapy, 72(3), 696-699.
- Li R#, Xie M#, Zhang J, Yang Z, Liu L, Liu X, Zheng Z, Chan EWC, Chen S. (2017). Genetic characterization of mcr-1-bearing plasmids to depict molecular mechanisms underlying dissemination of the colistin resistance determinant. Journal of Antimicrobial Chemotherapy, 72(2), 393-401.
- Lin D#, Xie M#, Li, R, Chen K, Chan EWC, Chen S. (2017). IncFII conjugative plasmid-mediated transmission of blaNDM-1 elements among animal-borne Escherichia coli strains. Antimicrobial agents and chemotherapy, 61(1), e02285-16.
- Huang Y#, Yu X#, Xie M#, Wang X, Liao K, Xue W, Chan EWC, Zhang R, Chen S. (2016). Widespread dissemination of carbapenem-resistant Escherichia coli sequence type 167 strains harboring blaNDM-5 in clinical settings in China. Antimicrobial agents and chemotherapy, 60(7), 4364-4368.
- Xie M, Lin D, Chen K, Chan EWC, Yao W, Chen S. (2016). Molecular characterization of Escherichia coli strains isolated from retail meat that harbor blaCTX-M and fosA3 genes. Antimicrobial agents and chemotherapy, 60(4), 2450-2455.
- Zhou H, Wang H, Chen K, Xie M, Yan Z, Zhang Y, Wu Y, Liu D, Wang J, Dong N, Cai C, Wu Y, Timothy R. WALSH, Chen S, Wang Y, & Zhang, R. (2024). Epidemiological and genomic analysis revealed the significant role of flies in dissemination of carbapenem-resistant Enterobacteriaceae (CRE) in China. Journal of Hazardous Materials, 480, 136374.
- Xu Q, Xie M, Liu X, Heng H, Wang H, Yang C, Chan EW, Zhang R, Yang G, Chen S. (2023) Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development. Signal Transduction and Targeted Therapy 8(1):221.
(# Contributed equally)
