Academic Staff
- GH180
- +852 3400 8787
- irene-hh.xiao@polyu.edu.hk
Research Overview
We are interested in studying the material basis and deep mechanism of herbal medicine and phytochemicals on metabolic diseases, and developing new drugs and supplements derived from food-medicine homologous substances.
Education and Academic Qualifications
- Doctor of Philosophy, Shenyang Pharmaceutical University
Academic and Professional Experience
Academic Membership
- Member, Guangdong Provincial Society of Experimental Pharmacology of Traditional Chinese Medicine (2022-2027)
- Member, Shenzhen Traditional Chinese Medicine Association (2019-Present)
- Member, Pharmaceutical Analysis Professional Committee, Shenzhen Pharmaceutical Society (2023-2026)
Academic Services
- Review Expert for Shenzhen Scientific Research Projects
- Guest Editor, Nutrients
- Guest Editor, Frontiers in Cell and Developmental Biology
- Reviewer Editor, Frontiers in Pharmacology
- Reviewer Editor, Frontiers in Endocrinology
Research Interests
Achievements
- Shenzhen Outstanding Postdoctoral Fellow (2016)
- Shenzhen Overseas High-Level Talent (Category C)
- Recipient of the Silver Medal at the Geneva International Invention Exhibition (2024)
- Xiao HH. The Role of Oxidative Stress and Natural Products in Maintaining Human Health. Nutrients, 2024, 16, 1268.
- Zhu YX, Tang ZL, Lu L, Qiu ZC, Pan DB, Yu Y, Xiao HH*, Wong MS. Exploring a novel class tryptophan hydroxylase 1inhibitor derived from Sambucus williamsii Hance for the osteoporosis treatment. Acupuncture and Herbal Medicine, 2024, 4(1): 102-112.
- Xiao HH, Zhu YX, Lu L, Zhou LP, Poon CCW, Chan CO, Wang LJ, Cao SS, Yu WX, Wong KY, Mok DKW, Wong MS. The lignan-rich fraction from Sambucus williamsii Hance exerts bone protective effects via altering circulating serotonin and gut microbiota in rats. Nutrients, 2022, 14, 4718.
- Qiu ZC, Zhang FX, Liu XL, Zhang YY, Tang ZL, Zhang J, Yang L, Wong MS, Chen JX*, Xiao HH*. Genistein modified with 8-prenyl group suppresses osteoclast activity directly via its prototype but not metabolite by gut microbiota. Molecules, 2022, 27: 7811.
- Xiao HH, Yu XL, Yang C, Chan CO, Lu L, Cao SS, Wan SW, Lan ZJ, Mok DKW, Chen S, Wong MS. Prenylated Isoflavonoids-Rich Extract of Erythrinae Cortex Exerted Bone Protective Effects by Modulating Gut Microbial Compositions and Metabolites in Ovariectomized Rats. Nutrients, 2021, 13, 2943. (IF: 6.706)
- Xiao HH, Lu Lu, Pong CW, Chan CO, Wang LJ, Zhu YX, Zhou LP, Cao SS, Yu WX, Wong KY, Mok DKW, Wong MS. The lignan-rich fraction from Sambucus Williamsii Hance ameliorates dyslipidemia and insulin resistance and modulates gut microbiota composition in ovariectomized rats. Biomedicine & Pharmacotherapy, 2021, 137:111372. (IF:7.419)
- Wu QC, Tang XY, Dai ZQ, Dai Y*, Xiao HH*, Yao XS. Sweroside promotes osteoblastic differentiation and mineralization via interaction of membrane estrogen receptor-α and GPR30 mediated p38 signaling pathway on MC3T3-E1 cells. Phytomedicine, 2019, 153146, doi.org/10.1016/j.phymed.2019.153146. (IF:4.268)
- Xiao HH, Lv J, Mok D, Yao XS, Wong MS, Cooper R. NMR applications for botanical mixtures: the use of HSQC data to determine lignan content in Sambucus williamsii. Journal of Natural Products, 2019, 82(7): 1733-1740. (IF:3.782)
- Xiao HH, Sham TT, Chan CO, Li MH, Chen X, Wu QC, Mok DKW, Yao XS, Wong MS. A metabolomics study on the bone protective effects of a lignan-rich fraction from Sambucus Williamsii Ramulus in aged rats. Frontiers in Pharmacology, 2018, 9:932. (IF: 4.225)
- Xiao HH, Zhang Y, Cooper R, Yao XS, Wong MS. Phytochemicals and potential health effects of Sambucus williamsii Hance (Jiegumu). Chinese Medicine, 2016, 11:36.
- Wong, MS, Poon CW, Zhou LP, Xiao HH. Natural Products as Potential Bone Therapies. Paula H eds., Bone Regulators and Osteoporosis Therapy, 2019, Chapter 19, p: 499-518. Springer International Publishing. Cham, Switzerland
- Xiao HH, Wong MS, Yao XS. A lignan-rich bioactive fraction of Sambucus williamsii Hance exerts oestrogen-like bone protective effects in aged ovariectomized rats and osteoblastic cells. Connie M. Weaver, Robin M. Daly, Heike A. Bischoff-Ferrari eds. Nutritional Influences on Bone Health. 9th International Symposium. Springer International Publishing AG, Cham, 2016, Chapter 13, p: 137-143.
