Academic Staff
- GH180
- +852 3400 8746
- qiwen.liao@polyu.edu.hk
ORCID ID
SCOPUS IDResearch Overview
My research focuses on the discovery and characterization of bioactive molecules from marine invertebrates, particularly peptides with therapeutic potential in neurodegenerative diseases. In parallel, I am interested in the structural pharmacology of G protein-coupled receptors (GPCRs) involved in innate immunity, with a particular interest in elucidating the molecular determinants of ligand efficacy and potency in chemoattractant GPCRs signaling.
Education and Academic Qualifications
- Bachelor of Science, South China Agricultural University
- Doctor of Philosophy in Biomedical Sciences, University of Macau
Research Interests
Achievements
- Zeng Z#, Liao Q#, Gan S#, Li X, Xiong T, Xu L, Li D, Jiang Y, Chen J, Ye RD, Du Y, Wong TS. Structural insights into the binding modes of Lanreotide and Pasireotide with somatostatin receptor 1. Acta Pharm Sin B. 2025. In press.
- Shen S#, Liao Q#, Lyu P, Wang J, Lin L. Myricanol prevents aging-related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5. MedComm. 2024 Jun;5(6):e566.
- Wang J#, Chen G#, Liao Q#, Lyu W, Liu A, Zhu L, Du Y, Ye RD. Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2214324120.
- Chen G#, Wang X#, Liao Q#, Ge Y, Jiao H, Chen Q, Liu Y, Lyu W, Zhu L, Zundert G, Robertson MJ, Skiniotis G, Du Y, Hu H, Ye RD. Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns. Nature Communications. 2022 Sep 5;13(1):5232.
- Liao Q, Ye RD. Structural and conformational studies of biased agonism through formyl peptide receptors. Am J Physiol Cell Physiology. 2022 May 1;322(5):C939-C947.
