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The Specific Pathogen Free (SPF) Grade Animal Laboratory

The Specific Pathogen Free (SPF) Grade Animal Laboratory ensures high quality and reproducibility of animal testing. The laboratory is designed according to the "National Standard for the Quality of Laboratory Animal, PRC". It is set up according to the barrier system, which imposes stringent controls on the flow of personnel and materials to prevent microbial contamination. The animal laboratory is inspected annually by the authority and granted with "The Guangdong SPF Grade Laboratory Animal Facility Certificate".

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The laboratory mainly accommodates KM mice, NIH mice, C57 mice, SD rats and nude mice for preventive and therapeutic studies. The animal laboratory allows reliable investigation of pharmacology, efficacy and safety evaluation of drugs under in vivo conditions.

 

The Pharmacology Laboratory

The Pharmacology Laboratory is equipped with the clinical chemistry analyzer and hematology analyzer to analyze the metabolites. Other sophisticated equipments are used to trace the radioactive biomarkers in animal studies to study the metabolism. Paraffin sectioning of tissues and organs for pathological investigation, e.g. in chronic toxicity study, can also be carried out. Cryostat can be used for sectioning of fresh tissues.

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Cell Culture Laboratory

Cell Culture Laboratory was well equipped for cellular investigations required in e.g. in vitro drug screening, study of action mechanisms, etc. With the equipment in the Molecular Pharmacology Laboratory, in-depth studies at the genetic and proteomic level can be carried out.

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Major Equipment:

Analytical Chemistry and Preparation

Xevo TQD (Triple Quadrupole Mass Spectrometer) 
Synapt G2 HDMS (Ion-mobility Quadrupole Time-of-Flight Mass Spectrometer)
Bruker AVANCE 400 MHz NMR Spectrometer 
Bruker HCT LC/MS
Novasep Hipersep Lab Industrial Scale Preparative HPLC System
Agilent 1100 Series HPLC System (DAD/ELSD)
Agilent 1200 Series HPLC System
Shimadzu Prominence LC-20A HPLC Systems
Agilent 1100 Series Purification System
Agilent 6890/5973N GC/MSD
Agilent 6890 GC System (FID/ECD)
Perkin Elmer Polarimeter
CAMAG Thin Layer Chromatography Analyzing System
GeneVac Centrifugal Evaporator System
Heidolph Laborota 4001 Series Rotary Evaporators
MBRAUN Glove Box (with Gas Purification) 
Metrohm 787 Karl-Fisher Moisture Titrator
SOTAX AT7 Off-line Semi-automated Dissolution Testing System
BINDER KBF 115 Constant Climate Chamber
Heto Drywinner DW8 Freeze Dryer System

Efficacy/Safety Evaluation and Molecular Biology

Specific Pathogen Free (SPF) Animal Laboratory 
Tecniplast Metabolic Cage (Mice & Rat)
Tecniplast Individually Ventilated Cage SealsafeTM
ADInstrument ML785 PowerLab/8SP
Roche Midtron® Junior II Urine Analyzer
TECO Coatron M1 Coagulation Analyzer
ESCO Equ/04 Class II Type A/B3 Biological Safety Cabinet 
Shel Lab 2323TC CO2 Incubator
Thermolyne Locator JR Dewar Storage System
Leica DM IL Inverted Microscope 
Leica DM L Binocular Microscope 
Bio-Rad CFX96 Real-time PCR Detection System 
BMG LUMIstar Galaxy/FLUOstar Galaxy Microplate Reader 
Bio-Rad ChemiDoc XRS Gel Documentation System
Hitachi 7100 automatic biochemical analyzer 

 

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