- Y846
- +852 3400 8711
- q.zhao@polyu.edu.hk
- Lab Webpage
ORCID ID
SCOPUS IDResearch Overview
(1) To systematically discover and characterize novel natural peptides, including human intracellular peptides and immunopeptides, with an emphasis on those encoded by small open reading frames (sORFs)
(2) To develop next-generation chemical proteomics methodologies and integrate multi-omics approaches to elucidate fundamental biological mechanisms and accelerate translational drug discovery
Research Interests
Education and Academic Qualifications
- Bachelor of Engineering, Xi'an Jiaotong University (Class of National Life Science Talents)
- Doctor of Philosophy, The University of Hong Kong
Academic and Professional Experience
- Editorial Board Member, Molecular & Cellular Proteomics (2019 - Present)
- Editorial Board Member, Chinese Chemical Letters (2023 - Present)
- Elected Council Member, The Human Proteome Organization (HUPO) (2022 - Present)
- Member, American Society for Mass Spectrometry (Permanent)
Achievements
- Rising Stars in Proteomics and Metabolomics Award, The Journal of Proteome Research (2024)
- ASMS Emerging Investigators in Mass Spectrometry Award, The Journal of the American Society for Mass Spectrometry (2021)
- Gordon Conference Travel Award (2015)
- Utrecht University Short-stay Fellowship (2011)
- Zhang, Y.; Yang, Y.; Li, K.; Chen, L.; Yang, Y.; Yang, C.; Xie, Z.; Wang, H.; Zhao, Q. Enhanced Discovery of Alternative Proteins (AltProts) in Mouse Cardiac Development Using Data-Independent Acquisition (DIA) Proteomics. Analytical Chemistry 2025, 97, 1517–1527. DOI: 10.1021/acs.analchem.4c02924
- Yang, Y.; Chen, C.; Li, K.; Zhang, Y.; Chen, L.; Shi, J.; Mu, Q.; Xu, Y.; Zhao, Q. Proteogenomics Reveals Microproteins in Activated T Cells. Mol Cell Proteomics 2025, 24, 100914. DOI: 10.1016/j.mcpro.2025.100914
- Li, S.; Zhang, H.-R.; Yang, Y.; Ko, B. C.-B.; Shang, J.; Guo, H.; Yang, D.; Wong, M.; Chan, R. W.-C.; Kung, K. K.-Y.; Zhao, Q. Imaging-Based High-Content Screening with Clickable Probes Identifies XPB Inhibitors. Angewandte Chemie International Edition 2025, 64, e202505585. DOI: https://doi.org/10.1002/anie.202505585
- Yang, Y.; Tse, Y. S.; Zhang, Q.; Wong, K. Y.; Yang, C.; Yang, Y.; Li, S.; Lau, K. W.; Charles, T. C.; Lam, T. C.; Zhao, Q. Multiplexed Target Profiling with Integrated Chemical Genomics and Chemical Proteomics. J Med Chem 2024, 67, 17542–17550. DOI: 10.1021/acs.jmedchem.4c01463
- Yang, Y.; Wang, H.; Zhang, Y.; Chen, L.; Chen, G.; Bao, Z.; Yang, Y.; Xie, Z.; Zhao, Q. An Optimized Proteomics Approach Reveals Novel Alternative Proteins in Mouse Liver Development. Mol Cell Proteomics 2023, 22, 100480. DOI: 10.1016/j.mcpro.2022.100480
- Li, J.; Dong, J.; Wang, W.; Yu, D.; Fan, X.; Hui, Y. C.; Lee, C. S. K.; Lam, W. H.; Alary, N.; Yang, Y.; Zhang, Y.; Zhao, Q.; Chen, C.-L.; Tye, B.-K.; Dang, S.; Zhai, Y. The human pre-replication complex is an open complex. Cell 2023, 186, 98–111.e121. DOI: https://doi.org/10.1016/j.cell.2022.12.00
- Leung, C. O. N.; Yang, Y.; Leung, R. W. H.; So, K. K. H.; Guo, H. J.; Lei, M. M. L.; Muliawan, G. K.; Gao, Y.; Yu, Q. Q.; Yun, J. P.; Ma, S.; Zhao, Q.; Lee, T. K. W. Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma. Nature Communications 2023, 14, 6699. DOI: 10.1038/s41467-023-42360-w
- Leeman-Neill, R. J.; Song, D.; Bizarro, J.; Wacheul, L.; Rothschild, G.; Singh, S.; Yang, Y.; Sarode, A. Y.; Gollapalli, K.; Wu, L.; Zhang, W.; Chen, Y.; Lauring, M. C.; Whisenant, D. E.; Bhavsar, S.; Lim, J.; Swerdlow, S. H.; Bhagat, G.; Zhao, Q.; Berchowitz, L. E.; Lafontaine, D. L. J.; Wang, J.; Basu, U. Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression. Nat Genet 2023, 55, 2160–2174. DOI: 10.1038/s41588-023-01561-1
- Guo, H.; Yang, Y.; Zhang, Q.; Deng, J.-R.; Yang, Y.; Li, S.; So, P.-K.; Lam, T. C.; Wong, M.-k.; Zhao, Q. Integrated Mass Spectrometry Reveals Celastrol As a Novel Catechol-O-methyltransferase Inhibitor. ACS Chemical Biology 2022, 17, 2003–2009. DOI: 10.1021/acschembio.2c00011
- Chen, L.; Zhang, Y.; Yang, Y.; Yang, Y.; Li, H.; Dong, X.; Wang, H.; Xie, Z.; Zhao, Q. An Integrated Approach for Discovering Noncanonical MHC-I Peptides Encoded by Small Open Reading Frames. Journal of the American Society for Mass Spectrometry 2021, 32, 2346–2357. DOI: 10.1021/jasms.1c00076
