Prof. Wong Wing-tak

Academic Staff

PolyU Scholars Hub

Deputy President and Provost & Chair Professor of Chemical Technology

M1713
+852 3400 8789
w.t.wong@polyu.edu.hk

PolyU Scholars Hub

ORCID ID

SCOPUS ID

Education and Academic Qualifications

Bachelor of Science, The University of Hong Kong
Master of Philosophy, The University of Hong Kong
Doctor of Science, University of Cambridge
Doctor of Philosophy, University of Cambridge

Professional Qualifications

Fellow of Royal Society of Chemistry
Chartered Scientist
Chartered Chemist

Research Overview

My research interests include the development of novel nanotheranostics for cancer treatment and novel lanthanide-based molecular probes for disease diagnosis.

Research Interests

Achievements

2000 Doctor of Science, University of Cambridge, UK
2001 Outstanding Young Researcher Award, HKU
2002 Croucher Senior Research Fellowship, The Croucher Foundation
2003 Outstanding Research Student Supervisor Award, HKU
2008 Outstanding Researcher Award, HKU
2012 Outstanding Achievement Award in Scientific Research for Institution of Higher Education of China
2015 Gold Award, 43rd International Exhibition of Inventions of Geneva
2020 Ministry of Education Higher Education Outstanding Scientific Research Output Award, Second-class Award in Natural Science

Wong WT, Chan WY "Optimized relaxivity and specificity hepatobiliary MRI contrast agent". U.S. Patent 7,767,196. 3 Aug 2010.
Yung KF, Wong WT, Kwong TL "Methods and catalysts for green biodiesel production from unrefined low grade feedstock". U.S. Patent 9,694,350. 4 Jul 2017.
Yung KF, Wong WT, Kwong TL "Methods and catalysts for green biodiesel production from unrefined low grade feedstock". European Patent 3274298. 9 Oct 2019.
Yung KF, Wong WT, Kwong TL, Lau PC "Catalyst and method for biodiesel production from unrefined low-grade oil and crude aqueous alcohols". U.S. Patent 20180265446A1.

B. Xu, H. Qiu, H. Wang, S. Liu, H. Li, S. Xu, L. Jiang, H. Hou, X. Zhao, X. Li, Y. Huang, Y. Gu*, W.-T. Wong*, S. Li*, H. Zhou*, “Anti-triggering receptor expressed on myeloid cells 2-conjugated nanovesicles loaded vadimezan reprogram tumor-associated macrophages to combat recurrent lung cancer”, ACS Nano 2025 Accepted.
X. Wang, Z. Xu, J. Wang, C. Wu, L. Zhang, C. Qian, Y. Luo*, Y. Gu*, W.-T. Wong* and D. Xiang*, “A mitochondria-targeted biomimetic nanomedicine capable of reversing drug resistance in colorectal cancer through mitochondrial dysfunction”, Adv. Sci. 2025, 12, 2410630.
X. Li, X. Wang, H. Qiu, S. Li, L.-H. Hugo Tse, W.-S. Lo, K.-H. Lui, H. Zhou*, Y. Gu*, W.-T. Wong*, “Engineering optimal gold nanorod-loaded hollow mesoporous organosilica nanotheranostics for NIR-II photoacoustic microscopy imaging and tumor synergistic therapy”, Chem. Eng. J. 2024, 498,155310.
X. Fang, D. Yang, X. Wu, K.-H. Lui, X. Li, W.-S. Lo, C. Li, Y. Zhang, G. Nie, L. Jiang*, Y. Gu*, B. Zhang*, W.-T. Wong*, “Theoretical calculation-guided engineering of Fe-Mn based dual-center single-atom catalysts for synergistic tumor therapy”, Chem. Eng. J. 2023, 474, 145675.
S. Li, K.-H. Lui, W.-S. Lau, J. Chen, W.-S. Lo, X. Li, Y. Gu*, L.-T. Lin*, W.-T. Wong*, “MSOT-guided nanotheranostics for synergistic mild photothermal therapy and chemotherapy to boost necroptosis/apoptosis”, ACS Appl. Mater. Interfaces 2022, 14(29): 33712-33725.
X. Fang, X. Wu*, Z. Li, L. Jiang, W.S. Lo, G. Chen, Y. Gu*, W.-T. Wong*, “Biomimetic anti-PD-1 peptide-loaded 2D FePSe₃ nanosheets for efficient photothermal and enhanced immune therapy with multimodal MR/PA/thermal imaging”, Adv. Sci. 2021, 8(2): 2003041.
L. Jiang, H.M. Mak, E.R.H. Walter, W.-T. Wong*, K.-L. Wong*, N.J. Long*, “A fluorescent probe for the discrimination of oxidation states of palladium”, Chem. Sci. 2021, 12(29): 9977-9982.
L. Zhu, W. Ma, M. Zhang, M.M.-L. Lee, W.-Y. Wong, B.-D. Chan, Q. Yang, W.-T. Wong*, W. C.-S. Tai*, C.-S. Lee*, “Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds”, Nat. Commun. 2018, 9, 1283.
L. Jiang, R. Lan, T. Huang, C.-F. Chan, H. Li, S. Lear, J. Zong, W.-Y. Wong, M.M.-L. Lee, B.-D. Chan, W.-L. Chan, W.-S. Lo, N.-K. Mak *, M.-L. Lung, H.-L. Lung, S.-W. Tsao, G.-S. Taylor, Z. Bian, W.C.-S. Tai, G.-L. Law*, W.-T. Wong*, S.-L. Cobb*, K.-L. Wong*, “EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein-Barr virus”, Nat. Biomed. Eng. 2017, 1(4): 0042.
C.-T. Yeung, K.-H. Yim, H.-Y. Wong, R. Pal, W.-S. Lo, S.-C. Yan, M. Y.-M. Wong, D. Yufit, Danil E. Smiles, L. J. McCormick, S.J. Teat, D.K. Shuh, W.-T. Wong*, G.-L. Law*, “Chiral transcription in self-assembled tetrahedral Eu₄L₆ chiral cages displaying sizable circularly polarized luminescence”, Nat. Commun. 2017, 8, 1128.

Long N. J. Wong WT. "The Chemistry of Molecular Imaging". Indianapolis (IN): Wiley; 2015 (Editor)
Wong WT Jin J., "Upconversion Nanoparticles for Bioimaging Application", The Rare Earth Elements, Edited by D.A. Atwood, 2012 Wiley.
Wong WT, K.W.Y. Chan "Gadolinium Complexes as MRI Contrast Agents for Diagonsis", Rare Earth Coordination Chemistry-Fundamentals and Applications, Edited by C.H. Huang, 2010 Wiley.
Wong WT "Compounds Containing Bonds between Fe and Other Transition Metals, Group 11, 12 elements", Comprehensive Organometallic Chemistry III, Edited by R.H. Crabtree and D.M.P. Mingos, 2006 Elsevier.
Wong WT "Heterometallic Ru/Os Containing Compounds", Comprehensive Organometallic Chemistry III, Edited by R.H. Crabtree and D.M.P. Mingos, 2006 Elsevier.