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Academic Staff

Prof. Simon M.Y. Lee
PolyU Scholars Hub

Prof. Lee Ming-yuen, Simon

Chair Professor of Biomedical Sciences

Research Overview

Professor LEE's research interests encompass a diverse array of vital areas, such as brain disorders, neurodegenerative diseases, oncology, drug discovery (natural products as well as Chinese medicine), environmental health and toxicology.

Education and Academic Qualifications

  • Doctor of Philosophy, The Chinese University of Hong Kong

Academic and Professional Experience

  • Editorial board member, The Federation of American Societies for Experimental Biology and Wiley Announce Publishing Partnership — FASEB BioAdvances (2017.5-present)
  • Editorial board member of Chinese Medicine (2013-present)
  • Editorial board member of Journal of Ethnopharmacology
  • Member, Commission of Experts and Consultants for the Appraisal of Proprietary Chinese Medicines, Macao Government
  • Member, WHO Collaborating Centre for Traditional Medicine (Macao)
  • Technical Expert of an ISO/IEC 17025 Accreditation Assessment. Innovation and Technology Commission (ITC), Hong Kong SAR Government (2012-present)
    香港創新科技署ISO/IEC 17025認證評審 技術專家
  • Member of the Board of Directors, Good Practice in Traditional Chinese Medicine Research Association
    中醫藥規範研究學會 委員
  • Deputy Editor, Newsletter of Good Practice in Traditional Chinese Medicine Research Association
  • Committee Member, Division of Neuropsychopharmacology, Chinese Pharmacological Society
    中國藥理學會神經精神藥理學專業委員會 委員
  • President of Director Board, Consortium of ‘Belt and Road’ and Portuguese-Speaking Countries for Natural Medicine Innovation (Macao)
    「一帶一路」及葡語系國家天然藥物創新聯盟(澳門) 理事長
  • Invited Committee Member, China Association for Science and Technology
    廣東省科學技術協會 特邀委員
  • Committee Member, Integration of Traditional Chinese Medicine and Western Medicine Subgroup, China Association of Gerontology and Geriatrics
    中國老年學和老年醫學學會中西醫結合分會 常務委員
  • Board member, Academic Subgroup of Free Radical Biology and Free Radical Medicine, Biophysical Society of China
    中國生物物理學會自由基生物學與自由基醫學分會 理事
  • Committee member, Chinese Medicine and Natural Medicine Pharmacology, Chinese Pharmacological Society (2019.10-present)
    中國藥理學會中藥與天然藥物藥理專業委員會 委員會委員 
  • Committee member, Committee of Neuropharmacology, Chinese Pharmacological Society (2018.10-present)
    中國藥理學會神經精神藥理學專業委員會 專業委員會委員
  • Vice President of Director Board, Macao Association for Promotion of Science and Technology (2013-present)
    澳門科學技術協進會 副理事長
  • Chairman, Macau Pharmacology Association
    澳門藥理協會 會長
  • Board Member of International Society for Chinese Medicine (2012-present)
    國際中醫藥學會 理事

Research Interests

  • Brain Disorders
  • Neurodegenerative Diseases
  • Oncology
  • Cancer
  • Drug Discovery
  • Natural Products
  • Environmental Health and Toxicology


  • Stanford's top 2% most highly cited scientists 2022 
  • 2022 Macao Science and Technology Award-2nd Natural Science Award (The Government of Macao Special Administrative Region), Project: Supramolecular cell based drug delivery system for targeted therapy of inflammatory disease and cancer
    2022澳門科學技術獎-自然科學二等獎: 項目名稱《超分子細胞”藥物遞送體系的構建及用於炎症和腫瘤的靶向治療》
  • 2020 Science and Technology Award-3rd Technological Invention Award (The Government of Macao Special Administrative Region), Project: A High Throughput Zebrafish Screening System
  • 2020 Science and Technology Award-3rd Technological Invention Award (The Government of Macao Special Administrative Region), Project: Environmental Friendly Pesticide
  • 2020 Shanghai Science and Technology Progress Award Second Prize
    2020 上海市科技進步獎二等獎:項目名稱《動脈粥樣硬化“虛致痰瘀”的演變機制及其相關心血管疾病的防治研究》
  • 2020 Shanghai Science and Technology Award of Integrative Medicine Third Prize
  • 1st Prize Award, Chinese Association of Integrative Medicine 2019
  • Gold Medal with the Congratulations of Jury, jointly organized by the World International, Intellectual Property Organization and the federal government of Switzerland, the International Exhibition of Inventions of Geneva, SWITZERLAND, 2019
    第47屆瑞士日內瓦國際發明展評判特別嘉許金獎:項目名稱“基於微流控技術的班馬魚篩選系統”,組織者“國際智慧財產權組織(WIPO)和瑞士聯邦政府”, 2019
  • Top 50 Projects of the High-value Patent Cultivation and Layout Competition in Guangdong-Hong Kong-Macao Greater Bay Area in 2019, Intellectual Property Office, The Zhuhai Municipal People's Government and Hengqin International Intellectual Property Exchange Center, CHINA
    《基於微流控技術的大規模活生物體及細胞篩選系統》獲得2019年粵港澳大灣區高價值專利培育佈局大賽 50強Incentive Award Scheme for Outstanding Academic Staff 2018/2019, University of Macau
  • 2017 Shanghai Science and Technology Award of Integrative Medicine 
    2017 中國中西醫結合學會科學技術獎
  • 2017 Shanghai Science and Technology Award上海市科學技術獎:項目名稱“三七花有效組分心血管保護作用的發現及保護作用機制的研究”,獎勵等級“三等獎”,組織者“上海市人民政府”,證書號“20174116-3-R04” 
  • Second Prize: the zebrafish In Vivo Chip Platform in the "Cross Straits, Hong Kong and Macau Collaborative Innovation Roadshow Competition”, organized by the Government of Macau, SAR, 2017
  • 2016 Shanghai Science and Technology Award of Integrative Medicine上海中西醫結合科學技術獎:項目名稱“三七花有效組分心血管保護作用的發現及作用機制的研究”,獎勵等級“二等獎”,組織者“上海市中西醫結合學會”,證書號“2016-13A-03”
  • 2016 Science and Technology Award-2nd Natural Science Award (The Government of Macao Special Administrative Region): Association Study of Pharmacology and Quality in Chinese Medicine 
    2016 澳門科學技術奬-自然科學奬二等奬:項目名稱《中藥質量評價關鍵科學問題的基礎研究及其應用》
  • 2012 Science and Technology Award-2nd Natural Science Award (The Government of Macao Special Administrative Region): Association Study of Pharmacology and Quality in Chinese Medicine
  • The 16th Chinese Pharmacological Society Servier Award for young Investigator in Pharmacology, Chinese Pharmacological Society and French Servier Research Institute, 2012
    第十六屆中國藥理學會SERVIER青年藥理工作者奬 2012
  • Popular Science Award: Project entitled “Application of zebrafish in drug screening for treatment of cardiovascular diseases” is selected as the most popular research projects in “Science is by your side: Vote for Your Favourite Local Science Researches”, organized by Macao Science Center, 2009
    澳門科學館最受歡迎研究項目奬 2009
  • UM Faculty Service Award, University of Macau, 2009
  • Microfluidic screening system
  • US Patent Pub. No.: US10392592B2; Pub. Date: 08/27/2019
  • European Patent Pub.  No.: EP3321681A1; Pub. Date: 16/05/2018
  • 基於微流控技術的大規模活體生物篩選系統

      中國專利號:CN106885807B; 授權公告日:24/04/2020

  • Novel Anti-Neurodegenerative Natural Compounds Isolated from Alpiniae Oxyphyllae Fructus and Their Total Synthesis
  • US Patent Pub. No.: US9475749B2; Pub. Date: 25/10/2016
  • European Patent Pub. No.: EP2970090B1; Pub. Date: 08/05/2019
  • Japan Patent Pub. No.: JP6422452B2; Pub. Date: 14/11/2018
  • Spain Patent Pub. No: ES2736599T3; Pub. Date: 03/01/2020
  • 分離自益智仁的新抗神經變性天然化合物及其全合成

      中國專利號: CN105431405B; 授權公告日: 01/06/2018

  • Uses Of Indole-Ketones Or Indolidones As Neuro-Protective Drugs
  • International PCT Pub. No: WO2013061279A4; Pub. Date: 2/5/2013
  •  US Patent Pub. No.: US9486440B2; Pub. Date: 08/11/2016
  • 吲哚酮類化合物在製備神經保護藥物中的應用

      中國專利號: CN102499917B; 授權公告日: 17/12/2014

  • Composition For Treating Dry Eye Diseases And Sjögren’s Syndrome
  • International PCT Pub. No: WO2017033060A1; Pub. Date: 02/03/2017
  •  US Patent Pub. No.: US11007177B2; Pub. Date: 18/05/2021
  • 用於治療乾眼病和斯耶格倫氐綜合症的組合

      中國專利號: CN107921022B; 授權公告日: 01/06/2021

  • 一種用於治療肺癌的藥物組合物
    中國專利號: CN105030746B; 授權公告日: 10/11/2017
  • 一種用於腦神經保護的藥物的組合
    中國專利號: CN102526021B; 授權公告日: 11/09/2013
  • 用於篩選抗血管損傷藥物的斑馬魚血管損傷模型及其建立方法和應用
    中國專利號: CN102499135B; 授權公告日:14/08/2013
  • 4,7-二氫四唑[1,5-á]嘧啶類化合物及其衍生物在製備預防或治療腦出血藥物中的應用
    中國專利號: CN103193780B; 授權公告日:08/07/2015
  • 三七花總皂苷在制備促進血管新生的藥物中的應用
    中國專利號: CN103893230B; 授權公告日:20/07/2016
  1. Gao C, et al. Surface-engineered chlorella alleviated hypoxic tumor microenvironment for enhanced chemotherapy and immunotherapy of first-line drugs. Materials Today. 2022. 
  2. Wong PK, et al. Physical, chemical, and cell toxicity properties of mature/aged particulate matter (PM) trapped in a diesel particulate filter (DPF) along with the results from freshly produced PM of a diesel engine. J Hazard Mater. 2022 Jul 15;434:128855. 
  3. Wong PK, et al. Physicochemical and cell toxicity properties of particulate matter (PM) from a diesel vehicle fueled with diesel, spent coffee ground biodiesel, and ethanol. Sci Total Environ. 2022 Jun 10;824:153873.
  4. Chen H, et al. Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis. Arch Toxicol. 2022 May 23. 
  5. Gao C, et al. In vivo hitchhiking of immune cells by intracellular self-assembly of bacteria-mimetic nanomedicine for targeted therapy of melanoma. Sci Adv. 2022 May 13;8(19):eabn1805. 
  6. Lee SM, et al. The Importance of Cooperating with China in the Global Health System. Rotas a Oriente. Revista de estudos sino-portugueses, 2022 (2), 127-147.
  7. Yuan Y, et al. Comparative genomics provides insights into the aquatic adaptations of mammals. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2106080118. 
  8. Gao C, et al. Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines. Nat Commun. 2020 May 26;11(1):2622. 
  9. Zhao YP, et al. Resequencing 545 ginkgo genomes across the world reveals the evolutionary history of the living fossil. Nat Commun. 2019 Sep 13;10(1):4201. 
  10. Gao C, et al. A user-friendly herbicide derived from photo-responsive supramolecular vesicles. Nat Commun. 2018.9: 2967 
  11. Zhang Q*, et al. The genetic architecture of floral traits in the woody plant Prunus mume. Nat Commun. 2018 Apr 27;9(1):1702.

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