Cancer is one of the most serious diseases that threaten the human health. It is very urgent to develop advanced technology for cancer diagnosis and therapy. The traditional cancer therapy methods include operation, chemotherapy and radiotherapy etc, which suffer from long treatment period, drug resistance, big side effect. The newly developed minimally invasive treatment processes such as photothermal (PTT)/photodynamic (PDT)/sonodynamic (SDT) therapy and immunoththerapy etc show great promise for cancer therapy, with advantages of good time-space selection, safe, low toxicity and minor side effects.
In this lecture, nanomaterials based photothermal and photodynamic therapy, sonodynamic therapy and immunotherapy will discussed. For NIR (laser)-triggered PTT and PDT, we will present metal/semiconductor heterojunction structure to increase photothermal conversion efficacy, Pd/Cu single-atom nano-enzyme to realize mild temperature PTT and double photosensitisers to improve ROS yield and increase the therapy efficacy in PDT. For sonodynamic therapy (SDT), we will discuss the design and optimization strategy of sonosensitizers, including defect engineering strategy and heterojunctions route. For immunotherapy, we will present how nanomaterials function in potentiating immune response, including immunogenic cell death (ICD), construction of tumor nanovaccines and pyroptosis adjuvants.
Finally, the future challenges for the application of nanomaterials in tumor therapy will be forecasted.