- Y722
- +852 3400 8730
- xiulian.yu@polyu.edu.hk
ORCID ID
SCOPUS IDResearch Overview
My research focuses on studying the molecular mechanism of a series of pore-forming proteins involved in host defense and pathogens invasion by using the state-of-art structural biology approaches such as cryoEM, cryoET and subtomogram averaging.
Research Interests
Education and Academic Qualifications
- Master of Science, Nankai University
- Doctor of Science, European Molecular Biology Laboratory
Achievements
- Yu, X.; Ni, T.; Munson, G.; Zhang, P.; Gilbert, R. J. C. Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation. Embo j 2022, 41, e111857. DOI: 10.15252/embj.2022111857
- Williams, S. I.; Yu, X.; Ni, T.; Gilbert, R. J. C.; Stansfeld, P. J. Structural, Functional and Computational Studies of Membrane Recognition by Plasmodium Perforin-Like Proteins 1 and 2. Journal of Molecular Biology 2022, 434, 167642. DOI: https://doi.org/10.1016/j.jmb.2022.167642
- ni, T.; Sun, Y.; Burn, W.; Al-Hazeem, M.; Zhu, Y.; Yu, X.; Liu, L.; Zhang, P. Structure and assembly of cargo Rubisco in two native α-carboxysomes. Nature Communications 2022, 13, 4299. DOI: 10.1038/s41467-022-32004-w
- Jiao, F.; Dehez, F.; Ni, T.; Yu, X.; Dittman, J. S.; Gilbert, R.; Chipot, C.; Scheuring, S. Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism. Nat Commun 2022, 13, 5039. DOI: 10.1038/s41467-022-32757-4
- Caggiano, M. P.; Yu, X.; Ohno, C.; Sappl, P.; Heisler, M. G. Live Imaging of Arabidopsis Leaf and Vegetative Meristem Development. Methods Mol Biol 2021, 2200, 295–302. DOI: 10.1007/978-1-0716-0880-7_13
- Ram, H.; Sahadevan, S.; Gale, N.; Caggiano, M. P.; Yu, X.; Ohno, C.; Heisler, M. G. An integrated analysis of cell-type specific gene expression reveals genes regulated by REVOLUTA and KANADI1 in the Arabidopsis shoot apical meristem. PLoS Genet 2020, 16, e1008661. DOI: 10.1371/journal.pgen.1008661
- Ni, T.; Jiao, F.; Yu, X.; Aden, S.; Ginger, L.; Williams, S. I.; Bai, F.; Pražák, V.; Karia, D.; Stansfeld, P.; Zhang, P.; Munson, G.; Anderluh, G.; Scheuring, S.; Gilbert, R. J. C. Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity. Science Advances 2020, 6, eaax8286. DOI: 10.1126/sciadv.aax8286
- Caggiano, M. P.; Yu, X.; Bhatia, N.; Larsson, A.; Ram, H.; Ohno, C. K.; Sappl, P.; Meyerowitz, E. M.; Jönsson, H.; Heisler, M. G. Cell type boundaries organize plant development. eLife 2017, 6, e27421. DOI: 10.7554/eLife.27421
- Xiong, J.; Cui, X.; Yuan, X.; Yu, X.; Sun, J.; Gong, Q. The Hippo/STE20 homolog SIK1 interacts with MOB1 to regulate cell proliferation and cell expansion in Arabidopsis. J Exp Bot 2016, 67, 1461–1475. DOI: 10.1093/jxb/erv538
