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Education and Academic Qualifications

  • Bachelor of Science, Fudan University
  • Master of Science, Fudan University
  • Doctor of Philosophy, Hong Kong University of Science and Technology

Research Overview

We are an interdisciplinary team in mass spectrometry, analytical chemistry, chemical biology and -omics. We develop and apply mass spectrometry-based approaches to address fundamental and applied problems in chemistry, biology, medicine, food science, information science, etc.

Academic and Professional Experiences

  • Panel Member for the Physical Sciences Subject (Joint Research Schemes), Hong Kong Research Grants Council, 2019 – present
  • Assessment Panel Member for the Biology and Medicine Subject (Competitive Research Funding Schemes for the Local Self-financing Degree Sector), Hong Kong Research Grants Council, 2019 – present
  • President, The Hong Kong Society of Mass Spectrometry, 2018 – present
  • International Committee Member, Asia Oceania Mass Spectrometry Society, 2017 – present
  • Member of Organic Analysis Committee, The Chinese Chemical Society, 2016 – present
  • Member, Asian CORE Program in Chemical Biology, 2011 – present
  • Series Editor for the book series on New Developments in Mass Spectrometry, The Royal Society of Chemistry, 2018 – 2022
  • Editorial Board Member, Rapid Communications in Mass Spectrometry, 2013 – present (2013 – 2020, associate member; 2020 – present, full member)
  • Editorial Board Member, Natural Products Chemistry & Research, 2012 – present
  • Editorial Board Member, Chemical Biology Letters, 2015 – present

Research Interests

  • Mass Spectrometry
  • Molecular Assembly and Recognition
  • Protein Structures, Dynamics and Interactions
  • Food Safety
  • Data Storage
  • Disease Biomarkers and Mechanisms of Biological Processes

Achievements

  • Most Valued Project Award (merit), The Hong Kong Polytechnic University, 2019
  • “Changbaishan Scholar” Chair Professor, Jilin Province, China, 2015-2018
  • Visiting Associate Professor, Kyoto University, 2013
  • RCUK Academic Fellowship, Research Council UK, 2006-2008.
  • First Class Prize (First Accomplisher), CAIA Award, The China Association for Instrumental Analysis (CAIA), 1995
 
  • Zhongping YAO, Cheuk Chi Albert NG, Francis Chung Ming Lau, Wai Man TAM, Data Storage Using Peptides, US Provisional Patent (Application No. 62/657,026, filed on 13 April 2018); PCT Patent (Application No. PCT/CN2018/119349, filed on 6 December 2018); US Non-Provisional Patent (Application No. 16/224,957, filed on 19 December 2018); US Continuation-in-part Patent (Application No. 16/949,04, filed on 12 October 2020).
  • Zhongping YAO, Cheuk Chi Albert NG, Tsz Tsun NG, Suying LI, Improved Edible Oil Analysis System and Method, PCT Patent (Application No. PCT/IB2017/053821, filed on 27 June 2017); US Patent (Application No. 15/628,043, filed on 27 June 2017, announcement date: 08 December 2020, announcement No. US10859552B2); Taiwan Patent (Application No. 106121410, filed on 27 June 2017, announcement date: 01 January 2021, announcement No. TWI714784B); EU Patent (Application No.17181140.9-1408, filed on13 July 2017); China Patent (Application No. 201710588321.1, filed on 19 July 2017).
  • Zhongping YAO, Tsz Tsun NG, Pui-Kin SO, A Method for Authentication of Edible Oils (鉴别食用油的方法), China Patent (Application No.: 201410538320.2, filed on 13 October 2014, Patent No.: ZL201410538320.2, announcement date: 02 July 2019, announcement No. CN 105486744 B).
  • Zhongping YAO, Haixing WANG, An Electrospray Ionization Device for Direct Analysis of Solid Samples (一種直接分析固體樣品的電噴霧電離裝置), China Patent (filed on 24th March 2014, Patent No.: 201320743737.3, announcement No. CN203674161U).
  • Zhongping YAO, Bin HU, Electrospray Ionization Device (電噴霧電離裝置), China Patent (filed on 27 January 2014, Patent No. 201310291014.9, announcement date: 08 February 2018, announcement No. CN104282524B).
  1. Ng, C. C. A.; Tam, W. M.; Yin, H. D.; Wu, Q.; So, P. K.; Wong, M. Y. M.; Lau, F. C. M.;* Yao, Z. P.* Data Storage Using Peptide Sequences, Nat. Commun. 2021, 12, 4242. DOI: 10.1038/s41467-021-24496-9.
  2. Huang, Y.;# Yin, H. D.;# Li, B. Y.;# Wu, Q.; Liu, Y.; Poljal, K.; Tang, X.; Wang, M.; Wu, Z. X.; Miller, E. A.; Jiang, L. W.; Yao, Z. P.;* Guo, Y. S.;* An in vitro Vesicle Formation Assay to Uncover Novel Factors that Mediate Vesicular Trafficking and Cargo Clients of a Specific Cellular Factor, Proc. Natl. Acad. Sci. USA 2021, 118, e2101287118. (#co-first author)
  3. Huang, L. W.; So, P. K.; Chen, Y. W.; Leung, Y. C.; Yao, Z. P.* Interdomain Flexibility and Interfacial Integrity of β-Lactamase Inhibitory Protein (BLIP) Modulate Its Binding to Class A β-Lactamases, J. Biol. Chem. 2021, 297, 100980. (Editors’ Pick)
  4. Li, S. Y.; Ng, T. T.; Yao, Z. P.* Quantitative Analysis of Blended Oils by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry and Partial Least Squares Regression, Food Chem. 2021, 334, 127601.
  5. Huang, L. W.; So, P. K.; Chen, Y. W.; Leung, Y. C.; Yao, Z. P.* Conformational Dynamics of Helix 10 Region as An Allosteric Site in Class A β-Lactamase Inhibitory Binding, J. Am. Chem. Soc. 2020, 124, 13756-13767.
  6. Wu, Q.; Wang, J. Y.; Han, D. Q.; Yao, Z. P.* Recent Advances in Differentiation of Isomers by Ion Mobility Mass Spectrometry, Trends Anal. Chem. 2020, 124, 115801. (Invited review)
  7. Han, D. Q.; Yao, Z. P.* Chiral Mass Spectrometry: An Overview, Trends Anal. Chem. 2020, 123, 115763. (Invited review)
  8. Huang, L. W.; So, P. K.; Yao, Z. P.* Protein Dynamics Revealed by Hydrogen Deuterium Exchange Mass Spectrometry: Correlation between Experiments and Simulation, Rapid Commun. Mass Spectrom. 2019, 33(S3), 83-89. (Invited Perspective article; Top Downloaded Paper 2018-2019 of the journal)
  9. Yu. X. Y.; Chau, M. C.; Tang, W. K.; Siu, C. K.;* Yao, Z. P.* Self-assembled Binuclear Cu(II)-Histidine Complex for Absolute Configuration and Enantiomeric Excess Determination of Naproxen by Tandem Mass Spectrometry, Anal. Chem. 2018, 90, 4089-4097.
  10. Hu, B.;# So, P. K.;# Yang, Y. Y.;* Deng, J. W.; Choi, Y. C.; Luan, T. G.; Yao, Z. P.* Surface-modified Wooden-tip Electrospray Ionization Mass Spectrometry for Enhanced Detection of Analytes in Complex Samples, Anal. Chem. 2018, 90, 1759-1766. (#co-first author)
  1. Liu, R.; So. P. K.; Wong, M. Y. M.; Hu, B.; Yao, Z. P. In Vivo Detection of Secondary Metabolites, In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Elsevier Press, 2016, chapter 11575. (DOI: 10.1016/B978-0-12-409547-2.11575-6).
  2. So. P. K.; Yao, Z. P. Expanding Role of Mass Spectrometry for Characterization of Proteins, In Peptides: Chemistry, Biology and Pharmaceutical Sciences, Wang, R. and Wang, K. R. Ed.; Chemical Industry Press, 2011, pp97-101. (ISBN: 978-7-122-10788-6)
  3. Yao, Z. P.; Tito, P.; Robinson C. V. Site Specific Hydrogen Exchange of Proteins: Insights into the Structures of Amyloidogenic Intermediates, In Biological Mass Spectrometry (Methods in Enzymology series, Volume 402); Burlingame, A. L., Ed.; Elsevier Press, 2005, chapter 12, pp389-402. (ISBN: 978-0-12-182807-3)

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