- Y723
- +852 3400 8667
- wilson-cy.lau@polyu.edu.hk
ORCID ID
SCOPUS IDResearch Overview
My research focuses on structural studies on macromolecular assemblies using state-of-the-art cryo-electron microscopy (cryo-EM). Specifically, my groups is interested in elucidating the structure-function relationship of biological machines and ligand discovery against 'undruggable' targets through rational design.
Research Interests
Education and Academic Qualifications
- Bachelor of Science, University of Toronto
- Doctor of Philosophy, University of Toronto
Achievements
- Yuan, D.; Zhang, Y.; Lim, K. H.; Leung, S. K. P.; Yang, X.; Liang, Y.; Lau, W. C. Y.; Chow, K. T.; Xia, J. Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes. Journal of the American Chemical Society 2022, 144, 18494–18503. DOI: 10.1021/jacs.2c07594
- Yu, C.; Leung, S. K. P.; Zhang, W.; Lai, L. T. F.; Chan, Y. K.; Wong, M. C.; Benlekbir, S.; Cui, Y.; Jiang, L.; Lau, W. C. Y. Structural basis of substrate recognition and thermal protection by a small heat shock protein. Nat Commun 2021, 12, 3007. DOI: 10.1038/s41467-021-23338-y
- Li, B.; Zeng, Y.; Cao, W.; Zhang, W.; Cheng, L.; Yin, H.; Wu, Q.; Wang, X.; Huang, Y.; Lau, W. C. Y.; Yao, Z. P.; Guo, Y.; Jiang, L. A distinct giant coat protein complex II vesicle population in Arabidopsis thaliana. Nat Plants 2021, 7, 1335–1346. DOI: 10.1038/s41477-021-00997-9
- Lai, L. T. F.; Yu, C.; Wong, J. S. K.; Lo, H. S.; Benlekbir, S.; Jiang, L.; Lau, W. C. Y. Subnanometer resolution cryo-EM structure of Arabidopsis thaliana ATG9. Autophagy 2020, 16, 575–583. DOI: 10.1080/15548627.2019.1639300
- Lai, L. T. F.; Ye, H.; Zhang, W.; Jiang, L.; Lau, W. C. Y. Structural Biology and Electron Microscopy of the Autophagy Molecular Machinery. Cells 2019, 8. DOI: 10.3390/cells8121627
- Kang, W.; Ma, T.; Liu, M.; Qu, J.; Liu, Z.; Zhang, H.; Shi, B.; Fu, S.; Ma, J.; Lai, L. T. F.; He, S.; Qu, J.; Wing-Ngor Au, S.; Ho Kang, B.; Yu Lau, W. C.; Deng, Z.; Xia, J.; Liu, T. Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux. Nature Communications 2019, 10, 4248. DOI: 10.1038/s41467-019-12247-w
- Sy, K. H. S.; Ho, L. W. C.; Lau, W. C. Y.; Ko, H.; Choi, C. H. J. Morphological Diversity, Protein Adsorption, and Cellular Uptake of Polydopamine-Coated Gold Nanoparticles. Langmuir 2018, 34, 14033–14045. DOI: 10.1021/acs.langmuir.8b02572
- Roh, S. H.; Kasembeli, M.; Galaz-Montoya, J. G.; Trnka, M.; Lau, W. C. Y.; Burlingame, A.; Chiu, W.; Tweardy, D. J. Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO. J Biol Chem 2016, 291, 4732–4741. DOI: 10.1074/jbc.M115.684878
- Lau, W. C. Y.; Li, Y.; Liu, Z.; Gao, Y.; Zhang, Q.; Huen, M. S. Structure of the human dimeric ATM kinase. Cell Cycle 2016, 15, 1117–1124. DOI: 10.1080/15384101.2016.1158362
- Lau, W. C. Y.; Li, Y.; Zhang, Q.; Huen, M. S. Molecular architecture of the Ub-PCNA/Pol η complex bound to DNA. Sci Rep 2015, 5, 15759. DOI: 10.1038/srep15759
