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Academic Staff

Prof. Dongsheng Liu
PolyU Scholars Hub

Prof. Liu Dongsheng

Chair Professor of Polymer Science and Chemical Biology

Research Overview

1. New strategy for synthesizing ultra-long single stranded DNA/RNA with site-specific modifications and circular mRNAs, and their applications in chemical biology, epigenetics and medicines;
2. Supramolecular hydrogels and their applications in tissue engineering.

Research Interests

  • DNA
  • RNA
  • Self-Assembly
  • Chemical Modification
  • Hydrogel
  • Tissue Engineering

Education and Academic Qualifications

  • Bachelor of Science, University of Science and Technology of China
  • Master of Science, Institute of Chemistry Chinese Academy of Science
  • Doctor of Philosophy, The Hong Kong Polytechnic University

Professional Qualifications

  • Fellow of Royal Society of Chemistry
  • Fellow of Chinese Chemical Society
  • Chang Jiang Scholar Chair Professorship

Academic and Professional Experience

  • Editor, European Polymer Journal
  • Associate Editor, Acta Polymerica Sinica
  • Associate Editor, Chem Res Chin Univ    
  • Associate Editor, Smart Molecules   
  • Secretary-General of Polymer Division, Chinese Chemical Society

Achievements

  • National High-level personnel of special support program (Leading Scientist) (2016)
  • The 7th CCS-BASF Youth Innovation Prize (2014)
  • The First CCS-RSC Young Scientist Award (2009)
  • Outstanding Young Scientist Funds of National Natural Science Foundation (2007)
  • 100 Talent Program Awards of Chinese Academy of Sciences (2005)
    1. Li, Y.; Chen, R.; Zhou, B.; Dong, Y.; Liu, D. Rational Design of DNA Hydrogels Based on Molecular Dynamics of Polymers. Advanced Materials 2024, 36, 2307129. DOI: https://doi.org/10.1002/adma.202307129
    2. Zhou, B.; Yang, B.; Liu, Q.; Jin, L.; Shao, Y.; Yuan, T.; Zhang, Y.-n.; Wang, C.; Shi, Z.; Li, X.; Pan, Y.; Qiao, N.; Xu, J.-F.; Yang, Y. R.; Dong, Y.; Xu, L.; Gui, S.; Liu, D. Effects of Univariate Stiffness and Degradation of DNA Hydrogels on the Transcriptomics of Neural Progenitor Cells. Journal of the American Chemical Society 2023, 145, 8954–8964. DOI: 10.1021/jacs.2c13373
    3. Li, X.; Dai, X.; Pan, Y.; Sun, Y.; Yang, B.; Chen, K.; Wang, Y.; Xu, J.-F.; Dong, Y.; Yang, Y. R.; Yan, L.-T.; Liu, D. Studies on the Synergistic Effect of Tandem Semi-Stable Complementary Domains on Sequence-Defined DNA Block Copolymers. Journal of the American Chemical Society 2022, 144, 21267–21277. DOI: 10.1021/jacs.2c08930
    4. Dong, Y.; Yang, Y.; Lin, C.; Liu, D. Frame-Guided Assembly of Amphiphiles. Accounts of Chemical Research 2022, 55, 1938–1948. DOI: 10.1021/acs.accounts.2c00234
    5. Dai, X.; Zhu, Z.; Li, Y.; Yang, B.; Xu, J.-F.; Dong, Y.; Zhou, X.; Yan, L.-T.; Liu, D. “Shutter” Effects Enhance Protein Diffusion in Dynamic and Rigid Molecular Networks. Journal of the American Chemical Society 2022, 144, 19017–19025. DOI: 10.1021/jacs.2c07830
    6. Yuan, T.; Shao, Y.; Zhou, X.; Liu, Q.; Zhu, Z.; Zhou, B.; Dong, Y.; Stephanopoulos, N.; Gui, S.; Yan, H.; Liu, D. Highly Permeable DNA Supramolecular Hydrogel Promotes Neurogenesis and Functional Recovery after Completely Transected Spinal Cord Injury. Advanced Materials 2021, 33, 2102428. DOI: https://doi.org/10.1002/adma.202102428
    7. Shi, J.; Jia, H.; Chen, H.; Wang, X.; Xu, J.-F.; Ren, W.; Zhao, J.; Zhou, X.; Dong, Y.; Liu, D. Concentration Insensitive Supramolecular Polymerization Enabled by Kinetically Interlocking Multiple-Units Strategy. CCS Chemistry 2019, 1, 296–303. DOI: 10.31635/ccschem.019.20190009
    8. Shao, Y.; Jia, H.; Cao, T.; Liu, D. Supramolecular Hydrogels Based on DNA Self-Assembly. Accounts of Chemical Research 2017, 50, 659–668. DOI: 10.1021/acs.accounts.6b00524
    9. Dong, Y.; Yang, Z.; Liu, D. DNA Nanotechnology Based on i-Motif Structures. Accounts of Chemical Research 2014, 47, 1853–1860. DOI: 10.1021/ar500073a
    10. Dong, Y.; Sun, Y.; Wang, L.; Wang, D.; Zhou, T.; Yang, Z.; Chen, Z.; Wang, Q.; Fan, Q.; Liu, D. Frame-Guided Assembly of Vesicles with Programmed Geometry and Dimensions. Angewandte Chemie International Edition 2014, 53, 2607–2610. DOI: https://doi.org/10.1002/anie.201310715 

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