- Y820-B
- +852 3400 8611
- xiuyuan.li@polyu.edu.hk
ORCID ID
SCOPUS IDResearch Overview
We develop chemical biology probes for in situ visualization of neural receptors, discover and engineer antibodies and peptides against challenging membrane proteins, and integrate cryogenic correlative imaging and multi-omics approaches to dissect synaptic plasticity.
Research Interests
Education and Academic Qualifications
- Bachelor of Science in Chemistry, The Massachusetts Institute of Technology
- Doctor of Philosophy in Chemistry, Stanford University
Achievements
- Kim, D.; Park, P.; Li, X.; Wong-Campos, J. D.; Tian, H.; Moult, E. M.; Grimm, J. B.; Lavis, L. D.; Cohen, A. E. EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation. Nature Neuroscience 2025, 28, 1099–1107. DOI: 10.1038/s41593-025-01922-5
- Lin, D.; Li, X.; Moult, E.; Park, P.; Tang, B.; Shen, H.; Grimm, J. B.; Falco, N.; Jia, B. Z.; Baker, D.; Lavis, L. D.; Cohen, A. E. Time-tagged ticker tapes for intracellular recordings. Nature Biotechnology 2023, 41, 631–639. DOI: 10.1038/s41587-022-01524-7
- Cogan, D. P.; Zhang, K.; Li, X.; Li, S.; Pintilie, G. D.; Roh, S.-H.; Craik, C. S.; Chiu, W.; Khosla, C. Mapping the catalytic conformations of an assembly-line polyketide synthase module. Science 2021, 374, 729–734. DOI: 10.1126/science.abi8358
- Cogan, D. P.; Li, X.; Sevillano, N.; Mathews, I. I.; Matsui, T.; Craik, C. S.; Khosla, C. Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction. Journal of the American Chemical Society 2020, 142, 14933–14939. DOI: 10.1021/jacs.0c05133
- Li, X.; Sevillano, N.; La Greca, F.; Hsu, J.; Mathews, I. I.; Matsui, T.; Craik, C. S.; Khosla, C. Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase. Biochemistry 2018, 57, 6201–6208. DOI: 10.1021/acs.biochem.8b00886
- Li, X.; Sevillano, N.; La Greca, F.; Deis, L.; Liu, Y.-C.; Deller, M. C.; Mathews, I. I.; Matsui, T.; Cane, D. E.; Craik, C. S.; Khosla, C. Structure–Function Analysis of the Extended Conformation of a Polyketide Synthase Module. Journal of the American Chemical Society 2018, 140, 6518–6521. DOI: 10.1021/jacs.8b02100
