- Y833
- +852 3400 8699
- ben.ko@polyu.edu.hk
ORCID ID
SCOPUS IDResearch Overview
Our team has three major research focuses: 1) Target elucidation of natural products using chemical biology and multi-onmics analysis; 2) Drug discovery and mechanistic study of hepatocellular carcinoma; 3) Mechanisms of cellular adaptation to change in extracellular tonicity.
Research Interests
Education and Academic Qualifications
- Bachelor of Science, The University of Hong Kong
- Doctor of Philosophy, The University of Hong Kong
Achievements
- CTCF inhibitors and their applications. Ko BC, Ma C, Cheung YC, Zhang YJ, Chan WC. Mainland China Patent (#201910562893.1)
- 一种半胱氨酸荧光探针及其制备方法与应用发明专利证书 (ZL 2021 1 0721493.8). 黄文健;柯桦怡;邓杰仁;柯子斌;陈颖祥
- Wang, C.-C.; Duan, J.; Mao, N.-D.; He, M.; Zhang, P.-P.; Yuan, Y.; Gao, Y.; He, X.; Shao, X.; Wang, S.; Hui, Z.; Zhang, H.; Ko, B. C. B.; Ye, X.-Y. A novel PARP-ATR dual inhibitor exhibits anti-triple-negative breast cancer activity by inducing excessive DNA damage in the mitotic phase. Biochemical Pharmacology 2025, 241, 117160. DOI: https://doi.org/10.1016/j.bcp.2025.117160
- Chan, W.-C.; Zhao, Q.; Wong, K. H.; Tang, H.-H.; Mok, D. K.-W.; Pardeshi, L.; Ruan, Y. C.; Yang, Y.; Wong, C.-M.; Wong, C. T. T.; Zhao, Y.-J.; Chan, K. Y.; Yin, Z.; Leung, H. H.-W.; Ma, X.; Chau, M. P.; Leung, F. K.-C.; Lui, Y.-Y.; Au, S. W.-N.; Sun, K.; Mok, C. Y.; Wang, F.; Ma, C.; Ho, Y.-H.; Ye, X.-Y.; Yeung, M. L.; Zhang, Y.; Zhao, Y. X.; Liu, J.; Wong, K.-H.; Chow, L. M. C.; Li, X. D.; Tse, G. M.; Wong, M.-K.; Shen, X.; Chiu, P.; Ko, B. C. B. Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism. Nature Communications 2025, 16, 6308. DOI: 10.1038/s41467-025-61565-9
- Cheung, C. Y.; Huang, T.-T.; Chow, N.; Zhang, S.; Zhao, Y.; Chau, M. P.; Chan, W. C.; Wong, C. C. L.; Boassa, D.; Phan, S.; Ellisman, M. H.; Yates, J. R., III; Xu, S.; Yu, Z.; Zhang, Y.; Zhang, R.; Ng, L. L.; Ko, B. C. B. Unconventional tonicity-regulated nuclear trafficking of NFAT5 mediated by KPNB1, XPOT and RUVBL2. Journal of Cell Science 2022, 135, jcs259280. DOI: 10.1242/jcs.259280
- Zhang, R.; Cheung, C.; Seo, S.-U.; Liu, H.; Pardeshi, L.; Wong, K.; Chow, L.; Chau, M.; Wang, Y.; Lee, A.; Kwon, W.; Chen, S.; Chan, B.; Wong, K.; Choy, R.; Ko, B. C. B RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in Macrophages via Regulating Histone H3K4 Trimethylation. Frontiers in Immunology 2021, 12, 679184. DOI: 10.3389/fimmu.2021.679184
- Zhang, B.; Zhang, Y.; Zou, X.; Chan, A. W. H.; Zhang, R.; Lee, T. K.-W.; Liu, H.; Lau, E. Y.-T.; Ho, N. P.-Y.; Lai, P. B. S.; Cheung, Y.-S.; To, K.-F.; Wong, H. K.; Choy, K. W.; Keng, V. W.; Chow, L. M. C.; Chan, K. K. Y.; Cheng, A. S.; Ko, B. C. B. The CCCTC-binding factor (CTCF)–forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma. The Journal of Pathology 2017, 243, 418–430. DOI: https://doi.org/10.1002/path.4976
- Special issue: The Role of Dietary Bioactive Compounds on Liver Cancer and Non-alcoholic Fatty Liver Disease Nutrients 2023 (https://www.mdpi.com/journal/nutrients/special_issues/KGYIFI83E5)
