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Prof. Wong Ka-Leung, Gary
PolyU Scholars Hub

Prof. Wong Ka-Leung, Gary

Chair Professor of Chemistry

Research Overview

Our research focuses on the development of new nanomaterials and nanocomposites for the applications in clean and renewable energy, including solar cell, water splitting, CO2 reduction, and batteries.

Research Interests

  • Nanotheranostics
  • Cancer Therapy
  • Lanthanide Chemistry
  • Molecular Probe
  • X-Ray Crystallography

Education and Academic Qualifications

  • Bachelor of Science in Biochemistry, The Hong Kong University of Science and Technology
  • Master of Philosophy, The University of Hong Kong
  • Doctor of Philosophy, The University of Hong Kong

Professional Qualifications

  • Fellow of the Royal Society of Chemistry
  • Chartered Chemist

Achievements

    • The Ministry of Education, second-class award at the Higher Education Outstanding Scientific Research Output Awards 2020 (Science and Technology) (2020)
    • ERES Junior award from The European Rare Earth and Actinide Society (2015)
    1. Lam, P.-L.; Wu, Yu.; Yao, L.; Kai, H.-Y.; Chau, H.-F.; Zhang, Q.; Zhou, W.; Bünzli, J.-C. G.; Wong, K.-L. One-step Assembly of α-Aryl-Substituted DOTAs as Superior and Universal Platforms for Multifunctional Theranostics. Angewandte Chemie International Edition 2025 Accepted.
    2. Wu, Y.; Wong, Y.-T.; Yeung, Y.-H.; Lam, P.-L.; Chau, H.-F.; Tam, W.-S.; Zhang, Q.; Tai, W. C. S.; Wong, K.-L. Peptide Multifunctionalization via Modular Construction of Trans-AB2C Porphyrin on Resin. Advanced Science 2025, 12, 2409771. DOI: https://doi.org/10.1002/advs.202409771
    3. Yeung, Y.-H.; Zhang, L.; Kai, H.-Y.; Lam, P.-L.; Zhang, T.; Wu, Y.; Law, G.-L.; Xie, C.; Wong, K.-L. Facilitating PET Imaging: Eco-Friendly Purification Using Solid-Phase Material for Labeling Metal-Based Radiopharmaceuticals. JACS Au 2025, 5, 3213–3218. DOI: 10.1021/jacsau.5c00394
    4. Thor, W.; Kai, H.-Y.; Yeung, Y.-H.; Wu, Y.; Cheung, T.-L.; Tam, L. K. B.; Zhang, Y.; Charbonnière, L. J.; Tanner, P. A.; Wong, K.-L. Unearthing the Real-Time Excited State Dynamics from Antenna to Rare Earth Ions Using Ultrafast Transient Absorption. JACS Au 2024, 4, 3813–3822. DOI: 10.1021/jacsau.4c00468
    5. Wu, Y.; Chau, H.-F.; Yeung, Y.-H.; Thor, W.; Kai, H.-Y.; Chan, W.-L.; Wong, K.-L. Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin. Angewandte Chemie International Edition 2022, 61, e202207532. DOI: https://doi.org/10.1002/anie.202207532
    6. Zha, S.; Chau, H.-F.; Chau, W. Y.; Chan, L. S.; Lin, J.; Lo, K. W.; Cho, W. C.-S.; Yip, Y. L.; Tsao, S. W.; Farrell, P. J.; Feng, L.; Di, J. M.; Law, G.-L.; Lung, H. L.; Wong, K.-L. Dual-Targeting Peptide-Guided Approach for Precision Delivery and Cancer Monitoring by Using a Safe Upconversion Nanoplatform. Advanced Science 2021, 8, 2002919. DOI: https://doi.org/10.1002/advs.202002919
    7. Wu, Y.; Chau, H.-F.; Thor, W.; Chan, K. H. Y.; Ma, X.; Chan, W.-L.; Long, N. J.; Wong, K.-L. Solid-Phase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction. Angewandte Chemie International Edition 2021, 60, 20301–20307. DOI: https://doi.org/10.1002/anie.202108885
    8. Thor, W.; Wu, Y.; Wang, L.; Zhang, Y.; Tanner, P. A.; Wong, K.-L. Charging and ultralong phosphorescence of lanthanide facilitated organic complex. Nature Communications 2021, 12, 6532. DOI: 10.1038/s41467-021-26927-z
    9. Zhang, J.-X.; Chan, W.-L.; Xie, C.; Zhou, Y.; Chau, H.-F.; Maity, P.; Harrison, G. T.; Amassian, A.; Mohammed, O. F.; Tanner, P. A.; Wong, W.-K.; Wong, K.-L. Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution. Light: Science & Applications 2019, 8, 46. DOI: 10.1038/s41377-019-0155-9.
    10. Jiang, L.; Lung, H. L.; Huang, T.; Lan, R.; Zha, S.; Chan, L. S.; Thor, W.; Tsoi, T.-H.; Chau, H.-F.; Boreström, C.; Cobb, S. L.; Tsao, S. W.; Bian, Z.-X.; Law, G.-L.; Wong, W.-T.; Tai, W. C.-S.; Chau, W. Y.; Du, Y.; Tang, L. H. X.; Chiang, A. K. S.; Middeldorp, J. M.; Lo, K.-W.; Mak, N. K.; Long, N. J.; Wong, K.-L. Reactivation of Epstein–Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating function. Proceedings of the National Academy of Sciences 2019, 116, 26614–26624. DOI: 10.1073/pnas.1915372116

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