Dr Xie Chen
Research Assistant Professor
- Y824-02
- +852 3400 2632
- chen-polyu.xie@polyu.edu.hk
ORCID ID
SCOPUS IDResearch Overview
My research is dedicated to advancing innovative strategies in medical imaging and therapeutics, utilizing AI to enhance discovery and application. By applying various types of radiation and exploring the unique functionalities of small molecules, I aim to develop safer, more efficient diagnostic and treatment options that enhance public health and patient outcomes.
Research Interests
Education and Academic Qualifications
- Master of Philosophy, Hong Kong Baptist University
- Doctor of Philosophy, University of Strasbourg, Strasbourg, France (jointly supervised with the Hong Kong Baptist University)
Achievements
- Yeung, Y.-H.; Zhang, L.; Kai, H.-Y.; Lam, P.-L.; Zhang, T.; Wu, Y.; Law, G.-L.; Xie, C.; Wong, K.-L. Facilitating PET Imaging: Eco-Friendly Purification Using Solid-Phase Material for Labeling Metal-Based Radiopharmaceuticals. JACS Au 2025, 5, 3213–3218. DOI: 10.1021/jacsau.5c00394
- Xie, C.; Li, X.; Zhang, L.; Chau, H.-F.; Thor, W.; Tam, W. S.; Woolley, B.; Jiang, M.; Ng, C.-F.; Botta, M.; Zhang, T.; Long, N. J.; Law, G.-L.; Wong, K.-L. Bimetallic porphyrin PET radiotracers for Low-Dose MRI contrast enhancement. Chemical Engineering Journal 2024, 495, 153350. DOI: https://doi.org/10.1016/j.cej.2024.153350
- Cheung, T.-L.; Tam, L. K. B.; Tam, W.-S.; Zhang, L.; Kai, H.-Y.; Thor, W.; Wu, Y.; Lam, P.-L.; Yeung, Y.-H.; Xie, C.; Chau, H.-F.; Lo, W.-S.; Zhang, T.; Wong, K.-L. Facile Peptide Macrocyclization and Multifunctionalization via Cyclen Installation. Small Methods 2024, 8, 2400006. DOI: https://doi.org/10.1002/smtd.202400006
- Xie, C.; Wu, Y.; Chau, H.-F.; Zhang, T.; Wong, C. T.; Yeung, Y.-H.; Lam, P.-L.; Bünzli, J.-C. G.; Charbonnière, L. J.; Law, G.-L.; Wong, K.-L. Multimodal Visualization of Bioorthogonal Systems by Off–On Luminescence and Enhanced Magnetic Resonance Imaging. Advanced Optical Materials 2023, 11, 2203057. DOI: https://doi.org/10.1002/adom.202203057
- Li, X.; Xie, C.; Zha, S.; Tam, W. S.; Jiang, M.; Wong, K.-L. Biocompatible Porphyrin-Peptide Conjugates as Theranostic Agents Targeting the Epstein-Barr Virus. ChemPlusChem 2022, 87, e202200184. DOI: https://doi.org/10.1002/cplu.202200184
- Chan, W.-L.; Xie, C.; Lo, W.-S.; Bünzli, J.-C. G.; Wong, W.-K.; Wong, K.-L. Lanthanide–tetrapyrrole complexes: synthesis, redox chemistry, photophysical properties, and photonic applications. Chemical Society Reviews 2021, 50, 12189–12257, 10.1039/C9CS00828D. DOI: 10.1039/C9CS00828D
- Zhang, J.-X.; Chan, W.-L.; Xie, C.; Zhou, Y.; Chau, H.-F.; Maity, P.; Harrison, G. T.; Amassian, A.; Mohammed, O. F.; Tanner, P. A.; Wong, W.-K.; Wong, K.-L. Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution. Light: Science & Applications 2019, 8, 46. DOI: 10.1038/s41377-019-0155-9
- Xie, C.; Chau, H.-F.; Zhang, J.-X.; Tong, S.; Jiang, L.; Fok, W.-Y.; Lung, H.-L.; Zha, S.; Zou, R.; Jiao, J.; Ng, C.-F.; Ma, P. a.; Zhang, J.; Lin, J.; Shiu, K. K.; Bünzli, J.-C. G.; Wong, W.-K.; Long, N. J.; Law, G.-L.; Wong, K.-L. Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement. Advanced Therapeutics 2019, 2, 1900068. DOI: https://doi.org/10.1002/adtp.201900068
- Yao, S.; Zheng, Y.; Jiang, L.; Xie, C.; Wu, F.; Huang, C.; Zhang, X.; Wong, K.-L.; Li, Z.; Wang, K. Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study. RSC Advances 2018, 8, 4472–4477, 10.1039/C7RA13176C. DOI: 10.1039/C7RA13176C
- Jiang, L.; Xie, C.; Lung, H. L.; Lo, K. W.; Law, G.-L.; Mak, N.-K.; Wong, K.-L. EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers. Theranostics 2018, 8, 5307–5319. DOI: 10.7150/thno.26823
- Chau, H.-F., Xie, C., Wong, K.-L., Development of "Smart" photodynamic theranostics agents (Book Chapter). Comprehensive Coordination Chemistry III, 2021, 9, 771-786.
