Dr Ng Cheuk-chi

Academic Staff

Research Assistant Professor

Y824-05
+852 3400 2609
cheuk-chi.a.ng@polyu.edu.hk

Research Overview

Our research interests lie in mass spectrometry, proteomics, chemical biology, and information technology, and the integration of these areas for interdisciplinary research, such as data storage using peptides and proteins and developing a peptide library for protein binding and drug development.

Research Interests

Achievements

Yao, Z. P.; Zhou, Y.; Ng, C. C. A.; Liu, C. X. Data storage using proteins. PCT application No. PCT/CN2023/108347 (filed 20/07/2023)
Yao, Z.; Ng, C. C. A.; Lau, C. M.; Tam, W. M. Sequencing data-encoded peptides from tandem mass spectra. EU patent No. EP 4261826 (granted 05/03/2025); US non-provisional patent application No. 18/297,685 (filed 10/04/2023); CN patent application No.: P24143CN00 (filed 10/04/2023)
Yao, Z. P.; Ng, C. C. A.; Lau, F. C. M.; Tam, W. M. Data storage using peptides. US patent No. 11,315,023 (granted 26/04/2022); EU patent No. EP 3776557 (granted 29/01/2025); CN patent No. ZL 201880094641.4 (granted 07/02/2025)
Yao, Z. P.; Ng, C. C. A.; Yin, H. D. Data storage using peptides. US continuation-in-part patent No. 11,302,421 B2 (granted 12/04/2022)
Yao, Z. P.; Ng, C. C. A.; Ng, T. T.; Li, S. Edible oil analysis system and method. US patent No. 10,859,552 (granted 08/12/2020)

Luo, X.; Ng, C. C. A.; Lam, H. H. N.; Yao, Z.-P. Advances in protein sequencing: Techniques, challenges and prospects. TrAC Trends in Analytical Chemistry 2025, 191, 118341. DOI: https://doi.org/10.1016/j.trac.2025.118341
Ng, C. C. A.; Zhou, Y.; Yao, Z.-P. Algorithms for de-novo sequencing of peptides by tandem mass spectrometry: A review. Analytica Chimica Acta 2023, 1268, 341330. DOI: https://doi.org/10.1016/j.aca.2023.341330
Ng, C. C. A.; Tam, W. M.; Yin, H.; Wu, Q.; So, P.-K.; Wong, M. Y.-M.; Lau, F. C. M.; Yao, Z.-P. Data storage using peptide sequences. Nature Communications 2021, 12, 4242. DOI: 10.1038/s41467-021-24496-9
Ng, T.-T.; Li, S.; Ng, C. C. A.; So, P.-K.; Wong, T.-F.; Li, Z.-Y.; Chan, S.-T.; Yao, Z.-P. Establishment of a spectral database for classification of edible oils using matrix-assisted laser desorption/ionization mass spectrometry. Food Chemistry 2018, 252, 335–342. DOI: https://doi.org/10.1016/j.foodchem.2018.01.125
Kundu, M.; Ng, C. C. A.; Petrovykh, D. Y.; Liu, L. Nickel foam supported mesoporous MnO2 nanosheet arrays with superior lithium storage performance. Chemical Communications 2013, 49, 8459–8461, 10.1039/C3CC44079F. DOI: 10.1039/C3CC44079F
Ng, C. C. A.; Magenau, A.; Ngalim, S. H.; Ciampi, S.; Chockalingham, M.; Harper, J. B.; Gaus, K.; Gooding, J. J. Using an Electrical Potential to Reversibly Switch Surfaces between Two States for Dynamically Controlling Cell Adhesion. Angewandte Chemie International Edition 2012, 51, 7706–7710. DOI: https://doi.org/10.1002/anie.201202118
James, M.; Darwish, T. A.; Ciampi, S.; Sylvester, S. O.; Zhang, Z.; Ng, A.; Gooding, J. J.; Hanley, T. L. Nanoscale condensation of water on self-assembled monolayers. Soft Matter 2011, 7, 5309–5318, 10.1039/C1SM05096F. DOI: 10.1039/C1SM05096F
Ng, C. C. A.; Saux, G. L.; Chockalingam, M.; Ciampi, S.; Harper, J. B.; Gooding, J. J. Preparation of thiol-terminated monolayers on silicon(100) surfaces using thioacetyl-protected alkynethiol. In 2010 International Conference on Nanoscience and Nanotechnology, 22–26 Feb. 2010, 2010; pp 244–247. DOI: 10.1109/ICONN.2010.6045195
Ng, C. C. A.; Ciampi, S.; Harper, J. B.; Gooding, J. J. Antifouling behaviour of silicon surfaces modified with self-assembled monolayers containing both ethylene glycol and charged moieties. Surface Science 2010, 604, 1388–1394. DOI: https://doi.org/10.1016/j.susc.2010.04.025
Ng, C. C. A.; Ciampi, S.; James, M.; Harper, J. B.; Gooding, J. J. Comparing the Reactivity of Alkynes and Alkenes on Silicon (100) Surfaces. Langmuir 2009, 25, 13934–13941. DOI: 10.1021/la901526e