
- Y824-01
- +852 3400 8610
- ho-fai.chau@polyu.edu.hk
Research Overview
Cancer therapy and the development of imaging agents are critical areas in biomedical research. Our team is focused on creating advanced theranostic agents that combine both therapeutic and imaging functions, enabling simultaneous treatment and real-time visualization of biological processes. This integrated approach allows for more targeted and effective cancer therapy while minimizing side effects, as clinicians can monitor treatment responses in real time and promptly adjust strategies to improve patient outcomes and quality of life.
A central aspect of our research involves studying the tumor microenvironment and identifying cancer proteins that are overexpressed in malignant cells. Using this knowledge, we design small-molecule therapeutics and imaging agents that act as intelligent, responsive probes, selectively targeting cancer cells to enhance treatment precision and efficacy. In addition to cellular studies, we employ organoid models—three-dimensional, patient-derived mini-organs—to better replicate the complexity of human tumors and refine our therapeutic approaches for more effective and personalized cancer management.
A major direction of our work is the engineering of bacteriophages to develop next-generation, target-specific anti-cancer theranostic agents. By leveraging the unique properties of phages, we aim to create highly selective delivery systems capable of recognizing and binding to cancer cells, thus facilitating both targeted therapy and precise imaging. This innovative strategy holds significant promise for improving the specificity and effectiveness of cancer treatments while reducing off-target effects, ultimately bridging the gap between diagnosis and therapy for individualized patient care.
Research Interests
Education and Academic Qualifications
- Bachelor of Science in Analytical and Testing Science, Hong Kong Baptist University
- Doctor of Philosophy in Chemistry, Hong Kong Baptist University
- Postdoctoral Fellow, Department of Surgery, The Chinese University of Hong Kong
- Teaching Fellow, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University
Achievements
- Tam, L. K. B.; Ma, W.; Li, B.; Thor, W.; Chau, H.-F.; Wong, K.-L. Rapid and sensitive determination of etomidate based on colorimetric assays with a chromium(iii) complex. Dalton Transactions 2025, 54, 10883–10889, 10.1039/D5DT00849B. DOI: 10.1039/D5DT00849B
- Yeung, Y.-H.; Chau, H.-F.; Kai, H.-Y.; Zhou, W.; Chan, K. H.-Y.; Thor, W.; Charbonnière, L. J.; Zhang, F.; Fan, Y.; Wu, Y.; Wong, K.-L. Near-Infrared and Visible Dual-Emitting Peptide by Modular Assembly of Nitrobenzoxadiazole and Neodymium Complexes. Advanced Optical Materials 2024, 12, 2302070. DOI: https://doi.org/10.1002/adom.202302070
- Xie, C.; Wu, Y.; Chau, H.-F.; Zhang, T.; Wong, C. T.; Yeung, Y.-H.; Lam, P.-L.; Bünzli, J.-C. G.; Charbonnière, L. J.; Law, G.-L.; Wong, K.-L. Multimodal Visualization of Bioorthogonal Systems by Off–On Luminescence and Enhanced Magnetic Resonance Imaging. Advanced Optical Materials 2023, 11, 2203057. DOI: https://doi.org/10.1002/adom.202203057
- Wu, Y.; Chau, H.-F.; Yeung, Y.-H.; Thor, W.; Kai, H.-Y.; Chan, W.-L.; Wong, K.-L. Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin. Angewandte Chemie International Edition 2022, 61, e202207532. DOI: https://doi.org/10.1002/anie.202207532
- Zha, S.; Chau, H.-F.; Chau, W. Y.; Chan, L. S.; Lin, J.; Lo, K. W.; Cho, W. C.-S.; Yip, Y. L.; Tsao, S. W.; Farrell, P. J.; Feng, L.; Di, J. M.; Law, G.-L.; Lung, H. L.; Wong, K.-L. Dual-Targeting Peptide-Guided Approach for Precision Delivery and Cancer Monitoring by Using a Safe Upconversion Nanoplatform. Advanced Science 2021, 8, 2002919. DOI: https://doi.org/10.1002/advs.202002919
- Chau, H.-F.; Wu, Y.; Fok, W.-Y.; Thor, W.; Cho, W. C.-S.; Ma, P. a.; Lin, J.; Mak, N.-K.; Bünzli, J.-C. G.; Jiang, L.; Long, N. J.; Lung, H. L.; Wong, K.-L. Lanthanide-Based Peptide-Directed Visible/Near-Infrared Imaging and Inhibition of LMP1. JACS Au 2021, 1, 1034–1043. DOI: 10.1021/jacsau.1c00187
- Wu, Y.; Tam, W.-S.; Chau, H.-F.; Kaur, S.; Thor, W.; Aik, W. S.; Chan, W.-L.; Zweckstetter, M.; Wong, K.-L. Solid-phase fluorescent BODIPY–peptide synthesis via in situ dipyrrin construction. Chemical Science 2020, 11, 11266–11273, 10.1039/D0SC04849F. DOI: 10.1039/D0SC04849F
- Zhang, J.-X.; Chan, W.-L.; Xie, C.; Zhou, Y.; Chau, H.-F.; Maity, P.; Harrison, G.; Amassian, A.; Mohammed, O.; Tanner, P.; Wong, W.-K.; Wong, K.-L. Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution. Light: Science & Applications 2019, 8. DOI: 10.1038/s41377-019-0155-9
- Xie, C.; Chau, H.-F.; Zhang, J.-X.; Tong, S.; Jiang, L.; Fok, W.-Y.; Lung, H.-L.; Zha, S.; Zou, R.; Jiao, J.; Ng, C.-F.; Ma, P. a.; Zhang, J.; Lin, J.; Shiu, K. K.; Bünzli, J.-C. G.; Wong, W.-K.; Long, N. J.; Law, G.-L.; Wong, K.-L. Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement. Advanced Therapeutics 2019, 2, 1900068. DOI: https://doi.org/10.1002/adtp.201900068
- Jiang, L.; Lung, H. L.; Huang, T.; Lan, R.; Zha, S.; Chan, L. S.; Thor, W.; Tsoi, T.-H.; Chau, H.-F.; Boreström, C.; Cobb, S. L.; Tsao, S. W.; Bian, Z.-X.; Law, G.-L.; Wong, W.-T.; Tai, W. C.-S.; Chau, W. Y.; Du, Y.; Tang, L. H. X.; Chiang, A. K. S.; Middeldorp, J. M.; Lo, K.-W.; Mak, N. K.; Long, N. J.; Wong, K.-L. Reactivation of Epstein–Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating function. Proceedings of the National Academy of Sciences 2019, 116, 26614–26624. DOI: 10.1073/pnas.1915372116
- Ho-Fai Chau, Chen Xie, Ka-Leung Wong, ‘Development of “Smart” Photodynamic Theranostics Agents’, Edwin C. Constable, Gerard Parkin, Lawrence Que Jr, editors. In: Comprehensive Coordination Chemistry III, Elsevier. (2021) Pages 771-786, ISBN 9780081026892