Liu Huaqian, a PhD student under the supervision of Prof. Zhao Xin, has been honored with the Best Poster Award at the 2025 Westlake Conference on Advanced Regenerative Engineering (WE-CARE).
Liu Huaqian's project, titled "Slot-in snap-back, homeothermal, shape memory bone screws loading L-arginine and Ca2+ propagate mechanical stimulation, energize bone cells, and augment bone regeneration," represents a significant leap forward in addressing the limitations of traditional metallic bone screws.
By pioneering a programmable shape memory polymer (SMP) screw, Huaqian has developed a revolutionary solution that combines mechanobiological activation through dynamic shape recovery mechanisms with the simultaneous activation of mechanosensitive Ca²⁺ channels and nitric oxide-cGMP signaling cascade. This innovative approach aims to overcome challenges such as stress shielding and delayed osseointegration, heralding a new era in bone regeneration techniques.
The theme of the WE-CARE conference, "breaking barriers among engineering, life science, medicine, and technology translation to transform training and patient care," provided an ideal backdrop for Liu Huaqian to unveil his pioneering research. His work not only promises accelerated callus maturation in preclinical models but also underscores the importance of coordinated bio-mechanical and bio-chemical stimulation in the realm of regenerative medicine.
Liu Huaqian's triumph at the WE-CARE conference underscores his dedication to advancing the frontiers of regenerative engineering and highlights the transformative potential of his research in revolutionizing orthopedic treatment strategies.
Liu Huaqian's project, titled "Slot-in snap-back, homeothermal, shape memory bone screws loading L-arginine and Ca2+ propagate mechanical stimulation, energize bone cells, and augment bone regeneration," represents a significant leap forward in addressing the limitations of traditional metallic bone screws.
By pioneering a programmable shape memory polymer (SMP) screw, Huaqian has developed a revolutionary solution that combines mechanobiological activation through dynamic shape recovery mechanisms with the simultaneous activation of mechanosensitive Ca²⁺ channels and nitric oxide-cGMP signaling cascade. This innovative approach aims to overcome challenges such as stress shielding and delayed osseointegration, heralding a new era in bone regeneration techniques.
The theme of the WE-CARE conference, "breaking barriers among engineering, life science, medicine, and technology translation to transform training and patient care," provided an ideal backdrop for Liu Huaqian to unveil his pioneering research. His work not only promises accelerated callus maturation in preclinical models but also underscores the importance of coordinated bio-mechanical and bio-chemical stimulation in the realm of regenerative medicine.
Liu Huaqian's triumph at the WE-CARE conference underscores his dedication to advancing the frontiers of regenerative engineering and highlights the transformative potential of his research in revolutionizing orthopedic treatment strategies.
