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Updates on the ULS Cryo-EM Centre

19 May 2023

Equipment update

The ULS is pleased to announce that our Cryo-Electron Microscopy (Cryo-EM) Centre is in the final stages of installation and testing, and will be open to users in the second half of 2023. The Centre is equipped with a collection of state-of-the-art instruments to support some of the latest techniques in structural biology, for example, single particle analysis (SPA), cryo-electron tomography (cryo-ET) and microcrystal electron diffraction (MicroED). To support SPA, cryo-ET and other cryo-EM workflows, the ULS is also in the process of acquiring a set of top-end GPU cluster and a high-capacity data storage server. The list of equipment at the ULS Cryo-EM Centre is as follows:


  • ThermoFisher Krios G4 300 kV Cryo-TEM System
  • ThermoFisher Glacios 200 kV Cryo-TEM System
  • ThermoFisher Talos L120C 120 kV TEM System
  • ThermoFisher Aquilos 2 Cryo-FIB System
  • GPU servers (2 units); each with 4× Nvidia A800 80 GB graphics cards
  • Data storage server (720 TB usable storage)
  • ThermoFisher Vitrobot Mark IV Plunge-freezing Systems (2 units)
  • Cressington 208C High Vacuum Turbo Carbon Coater
  • PELCO easiGlow Glow Discharge Cleaning System (2 units)


On the other hand, a symposium on biological cryo-EM will be held at the Institute for Advanced Study, HKUST, from 19th to 21st June, 2023, and is now accepting applications. Invited speakers from PolyU, other local universities, as well as renowned international scientists in the field will share their latest research and knowledge in cryo-EM with the participants. Potential users of our Cryo-EM Centre are encouraged to register for the symposium by the deadline on 9th June, 2023.


If you have any queries about the Cryo-EM Centre, equipment, or getting started in cryo-EM, please do not hesitate to contact Dr Michael Yuen or Mr Sirui Li of the ULS.


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