研究助理教授
- BC516
- 2766 4196
- pearl.chen@polyu.edu.hk
- 腦神經科學和神經康復
ORCID ID
SCOPUS ID簡歷
陳璐華博士在香港攻讀研究生課程之前，曾在中山大學附屬醫院接受臨床培訓並執業。她過往的臨床培訓經驗激發了她對神經精神障礙性疾病研究（從早期神經發育到晚期神經退行性變等）的興趣和熱情。在香港大學李嘉誠醫學院取得博士學位以後，她分別在香港大學和香港中文大學的心理學系接受了臨床神經科學的博士後培訓。
目前，陳博士的研究興趣旨在了解遺傳風險因素、環境風險因素和遺傳-環境相互作用如何導致神經精神疾病和相關行為／特徵的發生、發展和／或惡化。她使用系統科學的方法，再結合先進的跨學科分析手段，將多層次的信息和多學科的理論有機結合起來，以促進我們對人腦認知功能的理解。此外，她的研究興趣還包括鑒別認知功能的臨床表型以進行早期疾病診斷，並揭示社會和文化相關的風險因素。她的最終研究目標是將研究成果轉化為早期臨床干預措施，以幫助認知功能受損的患者。
研究興趣
研究成果
- Ma SL, Chen LH*, Lee CC, Lai K, Hung SF, Tang CP, Ho TP, Shea C, Mo F, Mak TSH, Sham PC, Leung PWL. Genetic overlap between attention deficit/hyperactivity disorder and autism spectrum disorder in SHANK2 gene. Frontier in Neuroscience (Section Neurogenomics), 2021, 27(15): 649588. (*Co-first author)
- Chen LH, Mak TSH, Fan YH, Ho DTY, Sham PC, Chu LW, Song YQ. Associations between CLU polymorphisms and memory performance: The role of serum lipids in Alzheimer’s disease. Journal of Psychiatric Research, 2020, 29(129): 281-288.
- Chen LH, Chu LW, Song YQ. Interlinking polymorphisms, estrogens and Alzheimer’s disease. In C Martin and V Preedy (Eds.), The neuroscience of dementia: Genetics, neurology, behavior and diet (pp. 25-39). Amsterdam, Netherlands: Elsevier, 2020.
- Li X, Wang J, Zhang R, Chen LH, Wang C, Ke J, Wang Y, Zhang Z. Psychological status and infection transmission conditions among anesthesiologists and operating room nurses during the outbreak period of COVID-19 in Wuhan, China. Frontiers in Psychiatry, 2020, 11: 574143.
- Shao L, Pan S, Zhang QP, Jamal M, Chen LH, Yin Q, Wu YJ, Xiong J, Xiao RJ, Kwong YL, Zhou FL, Lie AKW. A nonredundant role of innate lymphoid cells in the pathophysiology of graft-versus-host disease. Frontiers in Immunology, 2019, 6(10): 1233-1243.
- Yiend J, André J, Smith L, Chen LH, Toulopoulou T, Chen EYH, Sham PC, Parkinson B. Biased cognition in Eastern and Western cultures. PLoS One, 2019, 14(10): e0223358.
- Wang BB, Bao SY, Zhang ZG, Zhou XY, Wang J, Fan YH, Zhang Y, Li Y, Chen LH, Jia YZ, Li J, Li MX, Zheng WH, Mu N, Wang LQ, Yu Z, Wong DSM, Zhang YL, Kwan J, Mak HKF, Ambalavanan A, Zhou SR, Cai WW, Rouleau GA, Yang WL, Rogaeva E, Ma X, George-Hyslop PS, Chu LW, Song YQ. A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer’s disease in Hong Kong Chinese population. Neurobiology of Aging, 2018, 68: 160.e1-7.
- Chan MH, Leung PW, Ho TP, Hung SF, Lee CC, Tang CP, Cheung SK, Ching FY, Chan F, Chen LH, Garcia-Barcelo M, Sham PC. Are psychiatric comorbidities and associated cognitive functions related to treatment response to methylphenidate in boys with attention-deficit/hyperactivity disorder? Neuropsychiatric Disease and Treatment, 2017, 11(13): 1071-1080.
- Leung PW, Chan JK, Chen LH, Lee CC, Hung SF, Ho TP, Tang CP, Moyzis RK, Swanson JM. Family-based association study of DRD4 gene in methylphenidate-responded attention deficit/hyperactivity disorder. PLoS One, 2017, 12(3): e0173748.
- Chen LH, Kao PY, Fan YH, Ho DT, Ha JC, Chu LW, Song YQ. The genetic polymorphisms in estrogen metabolic pathway associated with risks of Alzheimer’s disease: Evidence from a southern Chinese population. Journal of the American Geriatrics Society, 2017, 65(2): 332-339.
- Chen LH, Kao PY, Fan YH, Ho DT, Chan CS, Yik PY, Ha JC, Chu LW, Song YQ. Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer’s disease in a southern Chinese population. Neurobiology of Aging, 2012, 33(1): 210.e1-7.
- Zhou L, Chan KH, Chu LW, Kwan JS, Song YQ, Chen LH, Ho PW, Cheng OY, Ho JW, Lam KS. Plasma Amyloid-β oligomer level is a biomarker for Alzheimer’s disease diagnosis. Biochemical and Biophysical Research Communications, 2012, 423(4): 697-702.
