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MHRC 人員

简历

Dr. Sonata Suk-yu Yau is an Associate Professor in the Department of Rehabilitation Sciences at Hong Kong Polytechnic University (PolyU). She earned her Bachelor's degree in Biochemistry from the Hong Kong University of Science and Technology and completed her Ph.D. in Neuroscience at the LKS Faculty of Medicine, University of Hong Kong (HKU). Prior to joining PolyU as an Assistant Professor, Dr. Yau received postdoctoral training through research fellowships funded by HKU and the Canadian Institutes of Health Research. She further expanded her research experience during a sabbatical at Stanford University, where she investigated mechanisms of aging-associated synaptic loss. Dr. Yau has broad training in the cellular and molecular neurobiology of psychiatric disorders, including depression, anxiety, and autism.  She has extensive experience using animal models to investigate how environmental factors, such as chronic stress and air pollutants, modulate neural plasticity, affecting mood and memory formation. Her research also explores therapeutic treatment targets, including physical exercise and Traditional Chinese Medicine (TCM), to mitigate neurodegeneration, with a special emphasis on the crosstalk between peripheral organs and the brain. Dr. Yau has published over 90 research articles and reviews, four book chapters, and holds patent in drug discovery. She has published in Molecular Psychiatry, PNAS, Neurobiology of Disease, Molecular Neurobiology and etc, with an H-index of 37 (Google Scholar 2026). She is recognized as an Expertscape Expert (2022), ranking top 1% scholar in adiponectin research. Her research is supported by external grants from the Hong Kong Research Council, the National Natural Science Foundation of China, and the Innovation Technology Commission of Hong Kong.

学历

  • Bachelor of Science in Biochemistry, The Hong Kong University of Science and Technology
  • Doctor of Philosophy, The University of Hong Kong

研究兴趣

  • Non-pharmacological and pharmacological treatments for cognitive impairment in diseased brains
  • Underlying mechanisms and biomarkers of physical exercise-induced brain plasticity

  • Formolo AD, THY Lee, Yau SY. (2019). Increasing adiponergic system activity as a potential treatment for depressive disorder. Molecular Neurobiology https://doi.org/10.1007/s12035-019-01644-3
  • Yau SY, Lee THY, Lee WL, Li LCK, Siu PM, Chan CCH. (2019) Effects of maternal exercise on adult hippocampal neurogenesis, temporal order memory and depression-like behaviour in adult female and male offspring. Front. Neurosci. https://doi.org/10.3389/fnins.2019.00470
  • Yau SY, Bettio L, Vetrici M, Truesdell A, Chiu C, Chiu J, Truesdell E, Christie BR. (2018) Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice. Neurobiology of Disease. 2018 Jan 29;113:11-22
  • Wang BL , Li A, Li XM, Ho WLP , Wu DH, Wang XQ, Liu ZH, Wu KKL, Yau SY, Xu AM, Cheng KK. (2018) Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system. EMBO Report. 2018 Feb 21. pii: e44977
  • Supriya R, Yu AP, Lee PH, Lai CW, Cheng KK, Yau SY, Chan LW, Yung BY, Siu PM. (2018) Yoga training modulates adipokines in adults with high-normal blood pressure and metabolic syndrome. Scand J Med Sci Sports. Mar;28(3):1130-1138
  • Yau SY, Bostrom C, Chiu J, Ghilan M, Chiu CY, Hryciw BN, Eadie BD, Christie BR. (2016) Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice. Neurobiology of Disease 19 (96):261-270
  • Bostrom C, Yau SY, Majaess N, Vetrici M, Gil-Mohapel J, Christie BR. (2016) Hippocampal deficits are associated with learning and memory impairment in Fragile X Syndrome. Neuroscience and Biobehavioral Reviews 68:563-574
  • Yau SY, Li A, Loo R, Ching YP, Christie BR, Lee TMC, Xu AM, So KF. (2014) Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. PNAS. 111 (44): 15810-15815
  • Lee TMC, Wong ML, Lau BMW, Lee JCD, Yau SY, So KF. (2014) Aerobic exercise interacts with neurotrophic factors to predict cognitive functioning in adolescents. Psychoneuroendocrinology 39: 214—224
  • Yau SY, Lau BWM, Tong JB, Wong R, Ching YP, Qiu G, Tang SW, Lee TMC, So KF. (2011) Hippocampal neurogenesis and dendritic plasticity support running-enhanced memory and depression-like behavior in stressed rats. PLosOne 6(9):e24263.

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