BME Research Seminar: Dynamics and Applications of Fluid-cell Interactions in Micro Channels

BME Research Seminar: Dynamics and Applications of Fluid-cell Interactions in Micro Channels

Overview of the Lecture

The measurement of single-cell mechanical properties with high-throughput gradually proves its value in various personalized medical technologies. While the mechanical properties of red blood cells play an important role in many chronic diseases related to blood, the superior deformability of red blood cells casts great challenge to measure their mechanical properties accurately at high throughput. Based on the mechanism of fluid-cell interactions in a narrow circular channel, a precise method for measuring mechanical properties of red blood cells including the shear modules, viscosity, surface area and cell volume is established and combined with machine learning methods. Precise measurement of mechanical properties of red blood cells provides a biophysical dimension to disease diagnosis which has important application prospects in the health management of blood-related diseases.

About the Speaker

Dr Xiaobo Gong is a professor of the Department of Engineering Mechanics, School of Ocean and Civil Engineering, Shanghai Jiao Tong University. He is also an adjunct professor of Engineering Research Center for Clinical Transformation of Digital Medicine, Ministry of Education, Shanghai Jiao Tong University. Deputy Director of the Department of Engineering Mechanics. Guest researcher of RIKEN, Japan. He is a member of the Biomechanics Committee of the Chinese Mechanics Society and the Chinese Society of Biomedical Engineering, an executive director of the Shanghai Biophysical Society, a deputy director of the Biomechanics Committee of the Shanghai Mechanics Society, and editorial board members of Mechanobiology in Medicine etc. His research interests focus on cellular scale biofluid mechanics, flexible microfluidic chip innovation, and cell mechanics for diseases detection. He has presided over a number of National Key Research and Development Programs and the National Natural Science Foundation of China. He has published more than 60 papers in PNAS, Lab Chip, JFM, etc.