BME Research Seminar: Cross Disciplinary Research on Medical and Engineering for Point-of-care Testing

BME Research Seminar: Cross Disciplinary Research on Medical and Engineering for Point-of-care Testing

Speaker: Prof. Hong Liu, Associate Dean, School of Biological Science and Medical Engineering, Southeast University

Time: 11:00 am - 12:00 noon (HK Time)

Mode: Hybrid

Venue: Room TU103, The Hong Kong Polytechnic University

Zoom: https://bit.ly/45E81Ae (Meeting ID: 986 6811 8692; Passcode: 690530)

Overview of the Lecture
Since the 1980s, various point of care testing (POCT) methods have emerged one after another, which can be roughly divided into two categories: biosensors (such as blood glucose meters) and test strips (such as early pregnancy test strips). However, with the integration of information science and biomedicine, especially the promotion of technological revolution such as mobile medicine and smart medicine, analytical chemistry faces new opportunities and challenges. The traditional POCT detection method has a single function, a large amount of blood collection, and low reliability of detection results, making it increasingly unable to meet the needs. Therefore, the development of new analytical chemistry methods and devices for on-site rapid detection has become a research hotspot at home and abroad.

Our team has been engaged in cross disciplinary research on POCT for a long time, involving original innovations and practical applications in detection materials, devices, and methods. The origami microfluidic chip that can be used for POCT was first proposed internationally and is collected by the History Museum of NIH in the United States. As the first/corresponding author in Nat Rev. Bioeng., Nat. Commun., Sci. Adv., J. Am. Chem. Soc., Angew. Chem. Int. Ed. and other publications have published more than 60 papers. Dr. Liu also received the Shulan Medical Youth Award, Outstanding Scientific and Technological Worker from the Chinese Electronics Society, and other honors.

In terms of POCT test paper materials, we have for the first time proposed a revolutionary photonic crystal "paper like" material internationally. By utilizing the fluorescence enhancement and photonic bandgap properties brought by the controllable ordered structure of the material, we have developed new methods for in vitro and in vivo detection of various biomarkers.

In terms of biosensors for POCT, we have developed innovative enzyme free metal sensors and proposed new sensing principles such as electrolysis water assistance for the first time internationally. We have developed non-invasive continuous monitoring methods and applied them to fields such as disease screening and health monitoring.

We propose a flexible device construction method based on gallium based room temperature liquid metal and magnetic field patterning for the emerging wearable flexible electronics. We have developed continuous monitoring equipment and matching algorithms for weak physiological signals, achieving long-term continuous monitoring of multiple physiological signals in complex environments.

About the Speaker

Prof. Hong Liu received his B.S. and M.S. from Nanjing University with Dr. Huangxian Ju, and he received his Ph.D. from the University of Texas at Austin in the USA with Dr. Richard M. Crooks. In 2013, he joined faculty team of Southeast University as a professor, and is now the associate dean of the School of Biological Science and Medical Engineering, responsible for the management of scientific research, laboratories, and instruments in the school. His research group is currently working on interdisplinary research on bioelectronics, especially for point-of-care applications.