| 应用生物及化学科技学系

Academic Staff

ORCID ID

SCOPUS ID

研究概述

(1) To systematically discover and characterize novel natural peptides, including human intracellular peptides and immunopeptides, with an emphasis on those encoded by small open reading frames (sORFs)
(2) To develop next-generation chemical proteomics methodologies and integrate multi-omics approaches to elucidate fundamental biological mechanisms and accelerate translational drug discovery

学历

Bachelor of Engineering, Xi'an Jiaotong University
Doctor of Philosophy, The University of Hong Kong

Academic and Professional Experience

Editorial Board Member, Molecular & Cellular Proteomics (2019 - Present)
Editorial Board Member, Chinese Chemical Letters (2023 - Present)
Elected Council Member, The Human Proteome Organization (HUPO) (2022 - Present)
Member, American Society for Mass Spectrometry (Permanent)

Rising Stars in Proteomics and Metabolomics Award, The Journal of Proteome Research (2024)
ASMS Emerging Investigators in Mass Spectrometry Award, The Journal of the American Society for Mass Spectrometry (2021)
Gordon Conference Travel Award (2015)
Utrecht University Short-stay Fellowship (2011)

Li SQ, Zhang HR, Yang Y, Ko BCB, Shang J, Guo HJ, Yang D, Wong MK, Chan RWC, Kung KKY, and Zhao Q*. Imaging-Based High-Content Screening with Clickable Probes Identifies XPB Inhibitors. Angewandte Chemie, 2025, e202505585.
Yang Y, Chen CM, Li KC, Zhang YL, Chen L, Shi J, Mu QH, Xu Y, Zhao Q*. Proteogenomic Profiling Reveals Small ORFs and Functional Microproteins in Activated T Cells. Molecular & Cellular Proteomics, 2025, 100914.
Zhang YL, Yang Y, Li KC, Chen L, Yang Y, Yang CX, Xie Z, Wang HW, Zhao Q*. Enhanced Discovery of Alternative Proteins (AltProts) in Mouse Cardiac Development Using Data-Independent Acquisition (DIA) Proteomics. Analytical Chemistry, 2025, 97(3), 1517-1527.
Yang Y, Tse YS, Zhang Q, Wong KY, Yang CX, Yang Y, Li SQ, Lau KW, Charles TC, Lam TC, Zhao Q*. Multiplexed Target Profiling with Integrated Chemical Genomics and Chemical Proteomics. Journal of Medicinal Chemistry, 2024, 67(19), 17542-17550.
Leeman-Neill RJ, Song D, Bizarro J, Wacheul L, Rothschild G, Singh S, Yang Y, Sarode AY, Gollapalli K, Wu LJ, Zhang WW, Chen YY, Lauring MC, Whisenant DE, Bhavsar S, Lim JH, Swerdlow SH, Bhagat G, Zhao Q, Berchowitz LE, Lafontaine DLJ, Wang JG*, Basu U*. Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression. Nature Genetics, 2023, 55, 2160–2174.
Leung CON, Yang Y, Leung RW, So KK, Guo HJ, Lei MM, Muliawan GK, Gao Y, Yu QQ, Yun JP, Ma S, Zhao Q*, Lee TK*. Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma. Nature Communications, 2023, 14, 6699.
Li J#, Dong JQ#, Wang WT#, Yu DQ#, Fan XY, Hui YC, Lee SK, Lam WH, Alary N, Yang Y, Zhao Q, Chen CL*, Tye BK*, Dang SY*, Zhai YL*. The Human pre-replication complex is an open complex. Cell, 2023, 186(1), 98-111.e21.
Yang Y#, Wang HW#, Zhang YL, Chen L, Chen GL, Bao ZS, Yang Y, Xie Z, Zhao Q*. An optimized proteomics approach reveals novel alternative proteins in mouse liver development. Molecular & Cellular Proteomics, 2022, 22(1), 100480.
Guo HJ#, Yang Y#, Zhang Q#, Deng JR, Yang Y, Li SQ, So PK, Lam TC, Wong MK, Zhao Q*. Integrated Mass Spectrometry Reveals Celastrol as a Novel Catechol-O-methyltransferase Inhibitor. ACS Chemical Biology, 2022, 17(8), 2003-2009.
Chen L, Zhang YL, Yang Y, Yang Y, Li HH, Dong X, Wang HW, Xie Z, Zhao Q*. An integrated approach for discovering non-canonical MHC-I peptides encoded by small open reading frames. Journal of the American Society for Mass Spectrometry, 2021, 32(9), 2346-2357.