Our research focuses on the innovation of cutting-edge catalysis reaction and its usage as a core technology to enrich organic chemistry to address the problems in pharmaceutical synthesis and to advance industrial and material science. We focus on five major areas: 1) design and development of new ligands; 2) application in chemo-, regio-, and enantioselective cross-coupling reactions; 3) and a variety of transition metal-catalyzed coupling reactions, e.g. the activation of inert carbon-heteroatom bond; 4) DFT study on reaction mechanisms; 5) synthesis of pharmaceutically active molecules and functional materials. By integrating catalyst design, mechanistic insight, and practical application, we aim to bridge fundamental discovery with real-world impact.