Gaussian curvature-driven direction of cell fate towards osteogenesis with triply periodic minimal surface scaffolds
Surface topology has demonstrated significant influence on regulating stem cell behaviours, functions and regenerating bone tissues. Notably, the hyperboloid structure is one that many species around the globe (e.g., coral calcification, leaves’ photosynthesis, mammalian trabecular bone) have adopted due to evolutionary advantages related to their amplified surface area, curvature, and energy dissipation.
To utilize the advantage of the architectural marvel of the hyperboloid structure, a novel three-dimensional (3D) Triply Periodic Minimal Surface (TPMS) scaffolds with varying Gaussian curvatures is developed to embody a trabecular bone mimicking hyperboloidal topography. The wavy TPMS scaffolds direct the osteogenic differentiation and angiogenic paracrine of mesenchymal stem cells through the hyperboloidal topography-induced cytoskeleton reorganization and nuclear deformation, accelerating the bone regeneration. The TPMS bone scaffolds can get a head start towards a simple, safe, efficient and personalized bone graft with notable clinical translation potential.
To utilize the advantage of the architectural marvel of the hyperboloid structure, a novel three-dimensional (3D) Triply Periodic Minimal Surface (TPMS) scaffolds with varying Gaussian curvatures is developed to embody a trabecular bone mimicking hyperboloidal topography. The wavy TPMS scaffolds direct the osteogenic differentiation and angiogenic paracrine of mesenchymal stem cells through the hyperboloidal topography-induced cytoskeleton reorganization and nuclear deformation, accelerating the bone regeneration. The TPMS bone scaffolds can get a head start towards a simple, safe, efficient and personalized bone graft with notable clinical translation potential.
