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Title of project:
Multi-neuronal firing patterns and visual signaling in the mouse retina: A multi-electrode array (MEA) study

Myopia is the leading cause of visual impairment and blindness. It has become a substantial public health problem worldwide. Although it is well established that defocused images alter eye growth and refraction contributing to myopia and that the retina can sense the focus of an image, “defocused images” effects on retinal signaling that accounts either for emmetropization or for refractive errors has remained elusive. This study using MEA technique aims to identify the cells and to understand the neuronal circuit that contributes to myopia to provide new insight and means for myopia prevention and modulation. This study can also help in developing the model for the detection of other diseases such as Retinal degenerations, Glaucoma, Retinopathy of prematurity.