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Dr TSE, Yan-yin Dennis

Dr TSE, Yan-yin Dennis
BSc, PhD
Assistant Professor

ORCiD 0000-0001-7561-9121
Author ID (Scopus) 23478668500

Biographical Sketch

Dr Dennis Tse obtained his BSc Optometry and PhD degrees from The Hong Kong Polytechnic University (PolyU). His early research focused on the modulation of refractive development by optical defocus in animal models. The basic scientific discoveries were later translated into clinical applications in the form of contact lenses and eyeglasses that effectively control myopia progression in children. Upon receiving his PhD, he spent two years in Australia as a postdoctoral fellow as part of a collaborative myopia research project between PolyU and the University of Newcastle. In 2011, he joined the Dept. of Ophthalmology of Baylor College of Medicine in the United States, where he received further postdoctoral training on retinal physiology from Prof. Samuel Miao-Sin Wu. He returned to his alma mater to serve as a Research Assistant Professor in late 2014, and was promoted to Assistant Professor in 2016. He is currently the subject leader of “Visual Science 4”, and “Management and Prevention of Refractive Error” in the School of Optometry.

Dr Tse’s current research interests include retinal neuroscience, mechanism and treatment of myopia, and the role of autophagy and oxidation in retinal degenerations. His research has been published in international journals including Autophagy, Nature Communications, Scientific Reports, Investigative Ophthalmology and Vision Science, British Journal of Ophthalmology, Experimental Eye Research, and Vision Research. He has been serving as an editorial board member for the journal “Scientific Reports” since 2016. He is currently a member of the department staffing committee of the school, and a member of the registration committee of the Optometrist Board of Hong Kong.

Dr Tse was named the 2012 Loris and David Rich Scholar by the International Retinal Research Foundation for his research on the pathogenesis of glaucoma. He was awarded a Grand Prize and Gold Medal with Jury's Commendation at the 39th International Exhibition of Inventions of Geneva in 2011 for his research on myopia. He was also an awardee of the Endeavour Cheung Kong Research Fellowship, and the Sir Edward Youde Memorial Fellowships in his earlier career. His research has been supported by the Research Impact Fund and General Research Fund from the Research Grants Council of HK, Innovation and Technology Support Programme, and Midstream Research Programme from the Innovation and Technology Commission of HK, as well as Large Equipment Funds from the PolyU.

Dr Tse welcomes young talent to join his research team. Postdoctoral, technical and student positions are available.  

Selected Publications 

  1. Palmieri M, Pal R, Nelvagal HR, et al. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nature Communications. 2017;8:14338.
  2. Tse DY, Lotfi P, Simons DL, Sardiello M, Wu SM. Electrophysiological and Histological Characterization of Rod-Cone Retinal Degeneration and Microglia Activation in a Mouse Model of Mucopolysaccharidosis Type IIIB. Scientific Reports. (2015); 5:17143.
  3. Lotfi P, Tse DY, Ronza A, Seymour ML, Martano G, Cooper JD, Pereira FA, Passafaro M, Wu SM, Sardiello M. Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. Autophagy. 2018;14(8):1419-1434
  4. Zheng H, Tse DY, Tang X, To CH and Lam TC. The interactions between bright light and competing defocus during emmetropization in chicks. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2932-2943