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About us > Our People > Academic Staff > Dr Bin LIN
Our People
Dr Henry CHAN | Dr Allen CHEONG | Prof. Pauline CHO | Dr Rachel CHUN | Dr Chi-wai DO | Dr Chea-su KEE | Prof. Carly LAM | Dr Andrew LAM | Dr Thomas LAM | Dr Jeffrey LEUNG | Dr Tina LIAN | Dr Bin LIN | Dr Jessica NEUVILLE | Dr Feng PAN | Dr Samantha SHAN | Dr Ellen TAN | Dr Patrick TING | Prof. Chi-ho TO | Dr Dennis TSE | Mr Jimmy TSE | Prof. George WOO | Prof. Maurice YAP

Dr Bin LIN

Dr Bin LIN
Associate Professor

ORCiD 0000-0003-1309-3480
Author ID (Scopus) 57204667165

Biographical Sketch

Dr Bin Lin received his PhD degree in visual neuroscience from The University of Sydney in 2002. After graduation, Dr Lin moved to the United States and received postdoctoral training at Harvard Medical School and Howard Hughes Medical Institute (HHMI), associated with the laboratory of Professor Richard Masland, and was promoted to Instructor a few years later. In the fall of 2009, Dr Lin moved to Hong Kong and took an Assistant Professor position at The University of Hong Kong. He joined the School of Optometry of The Hong Kong Polytechnic University as an Associate Professor in 2016. 

Dr Lin’s research interest focuses on neurodegeneration and neuroprotection in animal models of human retinal diseases, including retinitis pigmentosa (RP) and glaucoma. Specifically, his group applies a combination of molecular, immunohistochemical, and physiological approaches to dissect the cellular mechanisms underlying retinal neuronal death in these retinal diseases. Dr Lin’s group has demonstrated that neuroinflammation plays a pathological role in photoreceptor apoptosis in animal models of RP, and in retinal ganglion cell (RGC) death in mouse glaucoma models. His group will further explore key regulators of neuroinflammation, thereby helping to prevent neuroinflammation in RP and glaucoma. 

Another focus in Dr Lin’s research is to develop an optogenetic approach for treating blindness caused by photoreceptor degeneration, such as RP and age-related macular degeneration (AMD). His group uses an adeno-associated viral vector (AAV) coding for the photopigment melanopsin gene to transduce surviving retinal neurons in blind RP retinas. Proof of concept studies demonstrate that melanopsin-based gene therapy has great potential to restore light perception in humans suffering from photoreceptor loss.

Over the years, Dr Lin has published many papers in top peer-reviewed international journals in his field, including Neuron, PNAS and Journal of Neuroscience. Dr Lin was an invited speaker at several international conferences including the Gordon Research Conference and The International Society for Eye Research Biennial Meeting.

Selected Publications 

  1. Peng B, Xiao J, Wang K, So KF, Tipoe GL, Lin B. Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa. J Neurosci. 2014; 11;34(24):8139-50.
  2. Wang, K, Peng, B, Lin, B. Fractalkine receptor regulates microglial neurotoxicity in an experimental mouse glaucoma model. Glia (2014), 62: 1943–1954.
  3. Sümbül U, Song S, McCulloch K, Becker M, Lin B, Sanes JR, Masland RH and Seung SH. A genetic and computational approach to structurally classify neuronal types. Nature Communications. 2014; 5:3512.
  4. Lin B, Xiong G and Yang W. Ribosomal protein S6 kinase 1 promotes the survival of photoreceptors in retinitis pigmentosa. Cell Death and Disease (2018) 9:1141